Supplemental kentucky Bioinformatics Research infrastru*

描述（由申请人提供）：NIH-BRIN提案补充的主要目标是发展一个全州范围的科学研究核心（SRC）。SRC将在现有的KBRIN框架内为研究活动的能力建设提供动力。SRC将由一系列研究项目组成。这将需要扩大KBRIN，包括新的教师和学生的参与。为了最大限度地发挥机构资产和资源的杠杆作用，这两个子核心将分别强调研究密集型和综合性机构的优势。神经科学的重点将利用路易斯维尔大学和肯塔基大学这两所研究密集型机构的新兴优势，鼓励他们在众多研究活跃的实验室中开展合作和培训。这个子核心将使我们能够从综合机构吸引研究人员进入本州更大的基础生物医学研究工作之一，它将为我们提供在这一学科中建立额外能力的机会。第二个子核心将提供一个人口生物学的重点，这将利用10个综合性和主要本科院校的生物学系现有的师资力量，这些院校是kbrin的合作伙伴。这将有助于我们吸引更多的本科生参与到发现的过程中，而不是通过其他方式来完成。其目标是吸引学生（主要来自农村背景）了解研究的原理和实践，同时从事令人兴奋的野外生物学项目。本申请要求在这两个子核心中的每个子核心中支持六个新的研究项目。基因组学和生物信息学工具和方法的应用是这两个子核心的共同要素。因此，现有的KBRIN-行政、指导/培训、基因组学和生物信息学核心将是开发和实施SRC的主要参与者，并将为确保研究项目的成功提供支持作用。增加SRC的结果将是KBRIN更明确的研究重点。这将为肯塔基州生物医学研究和教育的发展提供更强有力的伙伴关系和多机构承诺。

DESCRIPTION (provided by applicant): The principal goal of this supplement to the NIH-BRIN proposal is to develop a statewide science research core (SRC). The SRC will provide the impetus to build capacity for research activities within the framework of the existing KBRIN. The SRC will consist of a set of research projects. This will entail an expansion of KBRIN to include new faculty and student participation. To maximize the leveraging potential of institutional assets and resources these two sub-cores will emphasize strengths in the research-intensive and comprehensive institutions respectively. A neuroscience focus will make use of emerging strengths of the two research-intensive institutions, the University of Louisville (UL) and the University of Kentucky (UK), to encourage collaborations and training in their numerous research-active laboratories. This sub-core will allow us to draw researchers from the comprehensive institutions into one of the larger basic-biomedical research endeavors within the state, and it will provide us the opportunity to build additional capacity in this discipline. The second sub-core will provide a population biology focus, and this will make use of existing faculty strengths in biology departments of the ten comprehensive and primarily undergraduate institutions that are KBRIN-partners. This will help us to engage a larger number of undergraduate students in the process of discovery than could otherwise be accomplished. The objective will be to attract students, mostly from rural backgrounds, into the principles and practices of research, while engaged in exciting projects in field biology. Support for six new research projects in each of these two sub-cores is requested in this application. The application of genomics and bioinformatics tools and methods are common elements of these two sub-cores. Therefore, the existing KBRIN- administrative, mentoring/training, genomics and bioinformatics cores will be major players in the development and implementation of the SRC, and will provide a supporting role to insure the success of the research projects. The outcome of adding the SRC will be a sharper research focus for the KBRIN. This will provide a stronger partnership and multi-institutional commitment to the development of biomedical research and education in the Commonwealth of Kentucky.