DNA Origami as a Vehicle for Implantable on Demand Drug Release

DNA 折纸作为植入式按需药物释放的载体

• 批准号: 2119082
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2119082
• 关键词: DNA; Origami; Vehicle; Implantable; Demand

DNA Nanotechnology provides a novel method of overcoming critical hurdles to successful, targeted drug delivery. Advanced oligonucleotide self-assembly techniques enable the formation of drug carrying, and eluting vehicles; ultimately aiding the localisation of a target molecule/drug, and enhancing efficacy.This project will seek to investigate oligonucleotide 'Origami' self-assemblies, and the incorporation of a specific, therapeutic oligonucleotide (drug) to the construct. Accompanying this will be a study into the loading of an assembled oligonucleotide structure on to a functionalised micro-electrode gold surface. Potential controlled loading, and release of the drug laden construct will also be assessed. The project will have some emphasis on microsystems engineering since implantable release mechanisms are a strong aim in the field of drug delivery since they offer a route towards targeted and confined release profiles.Finally, there will be significant emphasis given to drug release for cardiac conditions, particularly those involving use of a stent, particularly a drug releasing stent for therapy due to the expertise of the second supervisor.

DNA纳米技术提供了一种克服关键障碍的新方法，以成功的，有针对性的药物输送。先进的寡核苷酸自组装技术能够形成药物携带和洗脱载体;最终有助于靶分子/药物的定位，并提高疗效。本项目将寻求研究寡核苷酸“折纸”自组装，并将特定的治疗性寡核苷酸（药物）纳入构建体。伴随着这将是一个组装的寡核苷酸结构上的负载到功能化的微电极金表面的研究。还将评估载药构建体的潜在受控负载和释放。该项目将有一些重点的微系统工程，因为植入式释放机制是一个强大的目标，在药物输送领域，因为他们提供了一条通往有针对性的和有限的释放profiles.Finally，将有显着的重点给予心脏疾病的药物释放，特别是那些涉及使用支架，特别是药物释放支架治疗由于第二个主管的专业知识。