DNA Origami as a Vehicle for Implantable on Demand Drug Release

DNA纳米技术提供了一种克服关键障碍的新方法，可以成功地、有针对性地给药。先进的寡核苷酸自组装技术使药物载体和洗脱载体的形成；最终帮助目标分子/药物的定位，并提高疗效。本项目将寻求研究寡核苷酸‘折纸’自组装，以及将特定的治疗性寡核苷酸(药物)纳入构建。随之而来的是一项关于将组装的寡核苷酸结构负载到功能化微电极金表面的研究。还将评估载药结构的潜在受控加载和释放。该项目将侧重于微系统工程，因为植入型释放机制是药物释放领域的一个重要目标，因为它们提供了一条通向靶向和受限释放轮廓的途径。最后，由于第二主管的专业知识，将非常重视心脏疾病的药物释放，特别是那些涉及使用支架的药物释放，特别是用于治疗的药物释放支架。

DNA Nanotechnology provides a novel method of overcoming critical hurdles to successful, targeted drug delivery. Advanced oligonucleotide self-assembly techniques enable the formation of drug carrying, and eluting vehicles; ultimately aiding the localisation of a target molecule/drug, and enhancing efficacy.This project will seek to investigate oligonucleotide 'Origami' self-assemblies, and the incorporation of a specific, therapeutic oligonucleotide (drug) to the construct. Accompanying this will be a study into the loading of an assembled oligonucleotide structure on to a functionalised micro-electrode gold surface. Potential controlled loading, and release of the drug laden construct will also be assessed. The project will have some emphasis on microsystems engineering since implantable release mechanisms are a strong aim in the field of drug delivery since they offer a route towards targeted and confined release profiles.Finally, there will be significant emphasis given to drug release for cardiac conditions, particularly those involving use of a stent, particularly a drug releasing stent for therapy due to the expertise of the second supervisor.