Menstrual Cycle and Insulin Sensitivity in Diabetics

糖尿病患者的月经周期和胰岛素敏感性

• 批准号: 6647691
• 负责人: Kimberly Kovach Trout
• 金额: $ 2.94万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647691
• 关键词: blood glucose; clinical research; diabetes mellitus; female; glucose tolerance test; human subject; insulin sensitivity /resistance; medical complication; menstrual cycle; predoctoral investigator; premenstrual syndrome; serotonin; serotonin inhibitor; women's health

DESCRIPTION (provided by applicant): Type I diabetic women face the constant challenge of trying to maintain normal blood glucose levels to avoid the long-term complications of diabetes. Menstrual cycle changes during the luteal phase may contribute to fluctuations in glucose levels but definitive recommendations for adjustments of insulin dosage are not available due to conflicting experimental data. Some studies suggest that premenstrual syndrome (PMS) may exacerbate menstrual cycle changes in insulin sensitivity. Proposed Study I is designed to determine if there are differences in insulin sensitivity between the two phases of the menstrual cycle in Type I diabetic women with and without PMS. Diabetics may be particularly susceptible to PMS since previous studies suggest that PMS is related to low serotonin levels and diabetes itself may lead to low serotonin levels. Selective serotonin re-uptake inhibitors (SSRI's) have been used to successfully treat PMS in nondiabetic populations. In Type 2 obese diabetics, SSRI's have been shown to have a glucose-lowering effect, independent of weight loss. To date, no study has examined the use of SSRI's for the treatment of PMS in diabetic women. Study 2 will examine the effects of an SSRI on insulin sensitivity and PMS symptoms in Type I diabetic women with PMS. Insulin sensitivity will be measured using the frequently sampled intravenous glucose tolerance test.

描述（由申请人提供）：I型糖尿病女性面临着试图维持正常血糖水平以避免糖尿病长期并发症的持续挑战。 黄体期月经周期的变化可能导致血糖水平的波动，但由于实验数据相互矛盾，因此无法提供调整胰岛素剂量的明确建议。 一些研究表明，经前综合征（PMS）可能会加剧胰岛素敏感性的月经周期变化。 拟议的研究I的目的是确定是否有胰岛素敏感性的差异，在月经周期的两个阶段之间的I型糖尿病妇女和没有PMS。 糖尿病患者可能特别容易患经前综合症，因为之前的研究表明经前综合症与血清素水平低有关，而糖尿病本身可能导致血清素水平低。 选择性5-羟色胺再摄取抑制剂（SSRI）已成功用于治疗非糖尿病人群的PMS。 在2型肥胖糖尿病患者中，SSRI已被证明具有降糖作用，与体重减轻无关。 到目前为止，还没有研究检查SSRI用于治疗糖尿病女性的PMS。 研究2将检查SSRI对患有PMS的I型糖尿病女性的胰岛素敏感性和PMS症状的影响。 将使用频繁采样的静脉葡萄糖耐量试验测量胰岛素敏感性。