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Menstrual Cycle and Insulin Sensitivity in Diabetics

糖尿病患者的月经周期和胰岛素敏感性

基本信息

批准号：
6796282
负责人：
Kimberly Kovach Trout
金额：
$ 2.85万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-01 至 2005-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6796282
关键词：
blood glucose clinical research diabetes mellitus female glucose tolerance test human subject insulin sensitivity /resistance medical complication menstrual cycle predoctoral investigator premenstrual syndrome serotonin serotonin inhibitor women&apos s health

项目摘要

DESCRIPTION (provided by applicant): Type I diabetic women face the constant challenge of trying to maintain normal blood glucose levels to avoid the long-term complications of diabetes. Menstrual cycle changes during the luteal phase may contribute to fluctuations in glucose levels but definitive recommendations for adjustments of insulin dosage are not available due to conflicting experimental data. Some studies suggest that premenstrual syndrome (PMS) may exacerbate menstrual cycle changes in insulin sensitivity. Proposed Study I is designed to determine if there are differences in insulin sensitivity between the two phases of the menstrual cycle in Type I diabetic women with and without PMS. Diabetics may be particularly susceptible to PMS since previous studies suggest that PMS is related to low serotonin levels and diabetes itself may lead to low serotonin levels. Selective serotonin re-uptake inhibitors (SSRI's) have been used to successfully treat PMS in nondiabetic populations. In Type 2 obese diabetics, SSRI's have been shown to have a glucose-lowering effect, independent of weight loss. To date, no study has examined the use of SSRI's for the treatment of PMS in diabetic women. Study 2 will examine the effects of an SSRI on insulin sensitivity and PMS symptoms in Type I diabetic women with PMS. Insulin sensitivity will be measured using the frequently sampled intravenous glucose tolerance test.

描述（由申请人提供）：I 型糖尿病女性面临着努力维持正常血糖水平以避免糖尿病长期并发症的持续挑战。黄体期的月经周期变化可能会导致血糖水平波动，但由于实验数据相互矛盾，无法提供调整胰岛素剂量的明确建议。一些研究表明，经前综合症（PMS）可能会加剧月经周期胰岛素敏感性的变化。拟议的研究 I 旨在确定患有和不患有经前综合症的 I 型糖尿病女性在月经周期的两个阶段之间的胰岛素敏感性是否存在差异。糖尿病患者可能特别容易受到经前综合症的影响，因为之前的研究表明，经前综合症与低血清素水平有关，而糖尿病本身也可能导致低血清素水平。选择性血清素再摄取抑制剂 (SSRI) 已被用于成功治疗非糖尿病人群的经前综合症。对于 2 型肥胖糖尿病患者，SSRI 已被证明具有降血糖作用，与体重减轻无关。迄今为止，尚无研究检验 SSRI 治疗糖尿病女性经前综合症的用途。研究 2 将研究 SSRI 对患有经前综合症的 I 型糖尿病女性的胰岛素敏感性和经前综合症症状的影响。将使用频繁采样的静脉内葡萄糖耐量试验来测量胰岛素敏感性。