Neural Mechanisms of Sequential Control

描述：(申请人提供) 基底节在运动相关障碍中的作用，如 帕金森氏症，已经有了很好的记录。总的运动赤字 这些患者的部分原因是运动排序有困难。 行为，而这些缺陷可以被解释为与它们的基本元素分开 运动障碍。由于帕金森氏症患者的症状包括 过度学习的运动序列，这些运动序列背后的机制通常 “自动”行为可能与与生俱来的刻板印象更密切相关 序列，而不是通常在动物中使用的任意学习序列 测序模型。事实上，实验结果证实了这一观点。而当 受过良好学习的序列和先天序列的表示之间的相似性 是相当可观的，但它们并不完整。本提案的目标是 了解这两种顺序电机背后的神经机制 通过记录大鼠纹状体神经元的集合进行控制 执行自然的或习得的运动序列。神经活动，解剖区域， 神经元的相互作用将在这两种情况下进行比较和对比 运动序列。多巴胺能药物改变这两种类型的 顺序行为和相关的神经元活动也将被评估， 以进一步开发帕金森氏症的治疗策略。

DESCRIPTION:(provided by applicant) The role of the basal ganglia in movement related disorders, such as Parkinson's disease, has been well documented. The overall movement deficits of these patients are partly due to difficulties in the sequencing of motor actions, and these deficits can be construed as separate from their elemental motor difficulties. As symptoms of Parkinson's patients include deficits on over-learned movement sequences, the mechanisms underlying these normally "automated" behaviors may be more closely related to innate stereotypical sequences, than to the arbitrary learned sequences typically used in animal models of sequencing. Indeed, experimental results confirm this notion. While similarities between the representation of well-learned and innate sequences are considerable, they are not complete. The goal of the present proposal is to understand the neural mechanisms underlying both types of sequential motor control by recording from ensembles of striatal neurons in rats while they perform natural or learned motor sequences. Neural activity, anatomical area, and neuronal interactions will be compared and contrasted across these two motor sequences. The ability of dopaminergic drugs to alter both types of sequential behavior and the related neuronal activity will also be evaluated, in order to further develop treatment strategies for Parkinson's disease.