DYNAMICS OF STATE CARDIORESPIRATORY INTERACTIONS IN COCAINE EXPOSED INFANTS

这个项目正在尝试开发一个参数模型 海马体基于由 合作者肖维博士。肖维博士理论的形式主义 提供连续表示层次结构的方法 有组织的生理系统。在这种方法中，场方程 用来描述存在的生理过程的动力学 在突触水平(单个神经元的活动)和在 神经元水平(一组神经元的活动)。一个几何图形 模型被用来施加空间边界，以便扩散， 传播等可以根据同质性中的已知来限制 具有海马体特征的。到目前为止，场方程有 已适应兴奋性突触输入的特定情况 海马齿状颗粒细胞，以及一个几何模型 融合了脊椎骨的基本形态和解剖特征 已构建了进入齿状颗粒细胞的穿孔路径。 一群神经元的突触和动作电位活动， 每一个在远端树突上都有一群突触输入部位， 已经被模拟了。正在调查的具体问题是如何 将目前的二能级场论扩展到包括第三个能级， 分子水平，允许受体和 通道动力学。此项目的工作得到了Office的支持 海军研究部(编号：N00014-94-1-0568)授予肖韦教授。

This project is attempting to develop a parametric model of the hippocampus based on an n-level field theory developed by the collaborator, Dr. Chauvet. The formalisms of Dr. Chauvet's theory provide the means for a continuous representation of hierarchically organized physiological systems. In this approach, field equations are used to describe the dynamics of physiological processes existing at the synaptic level (activity of a single neuron) and at the neuronal level (activity of a population of neurons). A geometrical model is used to impose spatial boundaries so that diffusion, propagation, etc. can be limited according to known in homogeneities characteristic of the hippocampus. To date, the field equations have been adapted to the specific case of excitatory synaptic input to hippocampal dentate granule cells, and a geometrical model that incorporates the essential morphological and anatomical features of perforant path input to dentate granule cells has been constructed. The synaptic and action potential activity of a population of neurons, each having a population of synaptic input sites on distal dendrites, has been simulated. The specific problem being investigated is how to extend the current two-level field theory to include a third, molecular level that would allow representation of receptor and channel kinetics. Work in this project has been supported by Office of Naval Research (N00014-94-1-0568) to Professor Chauvet.