DYNAMICS OF STATE CARDIORESPIRATORY INTERACTIONS IN COCAINE EXPOSED INFANTS

该项目试图开发一个参数模型， 海马体的基础上的n级场理论开发的 合作者肖维医生 肖维博士理论的形式主义 提供了一种连续的分层表示方法， 有组织的生理系统。 在这种方法中，场方程 是用来描述生理过程的动力学 在突触水平（单个神经元的活动）和 神经元水平（神经元群体的活动）。 的几何 模型用于施加空间边界， 传播等可以根据已知的均匀性来限制 海马体的特征 到目前为止，场方程有 已经适应了兴奋性突触输入的特定情况， 海马齿状回颗粒细胞，和一个几何模型， 结合了基本的形态和解剖特征， 已构建了输入到齿状颗粒细胞的穿通通路。 一群神经元的突触和动作电位活动， 每个在远端树突上具有突触输入位点群， 已经被模拟了。 正在研究的具体问题是如何 将当前的两能级场论扩展到包括第三能级， 分子水平，这将允许代表受体和 通道动力学 该项目的工作得到了Office 海军研究所（N 00014 -94-1-0568）的研究报告。

This project is attempting to develop a parametric model of the hippocampus based on an n-level field theory developed by the collaborator, Dr. Chauvet. The formalisms of Dr. Chauvet's theory provide the means for a continuous representation of hierarchically organized physiological systems. In this approach, field equations are used to describe the dynamics of physiological processes existing at the synaptic level (activity of a single neuron) and at the neuronal level (activity of a population of neurons). A geometrical model is used to impose spatial boundaries so that diffusion, propagation, etc. can be limited according to known in homogeneities characteristic of the hippocampus. To date, the field equations have been adapted to the specific case of excitatory synaptic input to hippocampal dentate granule cells, and a geometrical model that incorporates the essential morphological and anatomical features of perforant path input to dentate granule cells has been constructed. The synaptic and action potential activity of a population of neurons, each having a population of synaptic input sites on distal dendrites, has been simulated. The specific problem being investigated is how to extend the current two-level field theory to include a third, molecular level that would allow representation of receptor and channel kinetics. Work in this project has been supported by Office of Naval Research (N00014-94-1-0568) to Professor Chauvet.