Structural Refinement of teixobactin for treating complex Propionbacteriam acnes infection

用于治疗复杂痤疮丙酸杆菌感染的 teixobactin 的结构精炼

• 批准号: 2123505
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2123505
• 关键词: Structural; Refinement; teixobactin; treating; complex

Propionibacterium acnes, an aerotolerant anaerobic Gram-positive organism, is commonly known as a skin commensal due to its colonisation of the sebaceous glands and hair follicles. However, P. acnes can act as an opportunistic pathogen to cause invasive infections, particularly those associated with medical implants. P. acnes is the most frequently isolated pathogen in prosthetic shoulder joint infections, and is increasingly found in medical device-related cerebro- and cardiovascular infections. Until recently, P. acnes has been susceptible to a wide range of antibiotics. However, over the past 2 decades, resistance to metronidazole, macrolides, tetracycline and trimethoprim-sulfamethoxazole has been observed with increasing frequency. Hence, new classes of antibiotics are necessary to specifically combat medical device-associated infections caused by P. acnes. Teixobactin is a recently discovered peptide antibiotic with potent antimicrobial activity against P. acnes. This project will entail the synthesis and microbiological evaluation of dual-action teixobactin analogues as potential antimicrobials for the treatment of P. acnes infections.

痤疮丙酸杆菌是一种耐氧厌氧革兰氏阳性生物，由于其在皮脂腺和毛囊中的定殖，通常被称为皮肤真菌。然而，痤疮丙酸杆菌可作为机会性病原体引起侵入性感染，特别是与医疗植入物相关的感染。痤疮丙酸杆菌是人工肩关节感染中最常见的分离病原体，并且越来越多地在医疗器械相关的脑和心血管感染中发现。直到最近，痤疮丙酸杆菌一直对多种抗生素敏感。然而，在过去的20年中，耐药甲硝唑，大环内酯类，四环素和甲氧苄啶磺胺甲恶唑已观察到的频率增加。因此，需要新型抗生素来专门对抗由痤疮丙酸杆菌引起的医疗器械相关感染。Teixobactin是最近发现的一种肽类抗生素，对痤疮丙酸杆菌具有有效的抗微生物活性。该项目将需要合成和微生物学评价双作用teixobactin类似物作为治疗痤疮丙酸杆菌感染的潜在抗菌剂。