Egf Receptor in Normal and Cancerous Intestinal Biology

描述(申请人提供)：表皮生长因子受体 (EGFR)是一种跨膜受体酪氨酸激酶，在 在发育过程中的大量组织，并与许多形式的 癌症。从小鼠基因敲除研究中，已知EGFR是 成熟肠道的成熟和/或维持。此外， 遗传学证据表明，在结直肠过程中需要EGFR 肿瘤发生学。尽管编码EGFR的基因并不是 已知在结直肠癌的发展过程中会发生突变。虽然癌症是 结肠癌和直肠癌是全球第三大最常见的癌症 美国是癌症死亡人数第二多的国家， 只有几个基因的作用得到了详细的研究；这些基因是典型的 在结直肠肿瘤发生过程中发生突变或与家族形式相关 这种疾病的危害。人们对这些基因知之甚少，这些基因似乎是 肿瘤发生的进展，但不会像EGFR那样自身发生突变。 因此，拟议研究的目标是(1)调查 EGFR在结直肠癌发生发展中的全球重要性，(2) 确定结直肠癌患者EGFR的时间需求 发展，(3)确定EGFR在肿瘤发生中的作用模式，以及 (4)探讨表皮生长因子受体在非上皮性室隔中的作用。 胃肠道。

DESCRIPTION (provided by applicant): The epidermal growth factor receptor (Egfr) is a transmembrane receptor tryrosine kinase that is required in numerous tissues during development and is associated with many forms of cancer. From mouse knockout studies, the Egfr is known to be required for the maturation and/or maintenance of the mature intestinal tract. Furthermore, genetic evidence suggests that the Egfr is required during colorectal tumorigenesis. This is despite that fact that the gene encoding Egfr is not known to be mutated during colorectal cancer development. Although cancer of the colon and rectum is the third most frequently diagnosed cancer in the United States and accounts for the second largest number of cancer deaths, the role of only a few genes has been studied in detail; these genes are typically mutated during colorectal tumorigenesis or are associated with familial forms of the disease. Little is know about genes that appear to be required for the progression of tumorigenesis but do not become mutated themselves like Egfr. The objectives of the proposed research are therefore (1) to investigate the global importance of Egfr during development of colorectal cancer, (2) to determine the temporal requirement for Egfr during colorectal cancer development, (3) to define the mode of action of Egfr during tumorigenesis, and (4) to investigate the function of Egfr in non-epithelial compartments of the gastrointestinal tract.