Asymmetric Catalysis by Transition Metals

描述（由申请人提供）：由于生命分子（肽、DNA/RNA、碳水化合物等）的“手性”，对映体化合物通常表现出截然不同的生物活性。因此，有必要开发有效的对映选择性有机合成方法。过渡金属催化了大量的转化，其中许多是其他类型的催化剂无法轻易完成的。本研究计划的重点是过渡金属催化过程的手性配体的开发。调查由两个部分组成：

DESCRIPTION (provided by applicant): Due to the "handedness" of the molecules of life (peptides, DNA/RNA, carbohydrates, etc.), enantiomeric compounds often display quite different biological activity. As a result, there is a need for the development of efficient methods for enantioselective organic synthesis. Transition metals catalyze a tremendous array of transformations, many of which cannot readily be accomplished by other types of catalysts. This research program focuses on the development of chiral ligands for transition metal-catalyzed processes. The investigation is comprised of two parts:  the synthesis of new families of ligands based on planar-chiral heterocycles.  the application of these new ligands to the development of highly enantioselective transition metal-catalyzed reactions.