Asymmetric Catalysis by Transition Metals

过渡金属的不对称催化

• 批准号: 6686988
• 负责人: GREGORY C FU
• 金额: $ 31.65万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6686988
• 关键词: catalyst; chemical reaction; chemical synthesis; heavy metals; heterocyclic compounds; ligands; molecular shape; stereochemistry; stereoisomer

DESCRIPTION (provided by applicant): Due to the "handedness" of the molecules of life (peptides, DNA/RNA, carbohydrates, etc.), enantiomeric compounds often display quite different biological activity. As a result, there is a need for the development of efficient methods for enantioselective organic synthesis. Transition metals catalyze a tremendous array of transformations, many of which cannot readily be accomplished by other types of catalysts. This research program focuses on the development of chiral ligands for transition metal-catalyzed processes. The investigation is comprised of two parts:  the synthesis of new families of ligands based on planar-chiral heterocycles.  the application of these new ligands to the development of highly enantioselective transition metal-catalyzed reactions.

描述（由申请人提供）：由于生命分子（肽、DNA/RNA、碳水化合物等）的“手性”，对映体化合物通常显示出相当不同的生物活性。因此，有必要开发高效的方法用于对映选择性有机合成。过渡金属催化了大量的转化，其中许多转化不能通过其他类型的催化剂容易地完成。该研究计划的重点是过渡金属催化过程中的手性配体的发展。调查由两部分组成：  平面手性杂环配体的合成。  这些新的配体的应用开发高对映选择性的过渡金属催化反应。