Palladium- and Nickel-Catalyzed C-C Bond Formation

描述(申请人提供)：钯和镍催化的交叉偶联反应在有机化学中是非常强大的工具，它们被应用于一系列生物活性目标的全合成，包括凋亡素、盘状内酯、龙胆醇、孢毒素、瑞斯托菌素苷元和紫杉醇。 在即将到来的赠款期间，该计划将探索交叉偶联反应的新维度-涉及烷基亲电试剂作为底物的过程。努力将重点放在开发多功能催化剂，包括手性催化剂，用于铃木、Negishi、Hiyama、Stille和Sonogashira反应等碳-碳键形成转化。机理研究将在这个项目中发挥重要作用，因为对金属反应性的更好理解应该会极大地促进催化剂的开发。

DESCRIPTION (provided by applicant): Palladium- and nickel-catalyzed cross-coupling reactions serve as extremely powerful tools in organic chemistry, and they been applied to the total synthesis of a wide array of biologically active targets, including apoptolidin, discodermolide, gambierol, palytoxin, ristocetin aglycone, and taxol. During the upcoming grant period, this program will explore a new dimension of cross-coupling reactions-processes that involve alkyl electrophiles as substrates. Efforts will focus on the development of versatile catalysts, including chiral catalysts, for carbon-carbon bond-forming transformations such as the Suzuki, Negishi, Hiyama, Stille, and Sonogashira reactions. Mechanistic studies will play an important role in this project, since an improved understanding of metal-based reactivity should greatly facilitate catalyst development.