Asymmetric Catalysis by Transition Metals

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DESCRIPTION (provided by applicant): Due to the "handedness" of the molecules of life (peptides, DNA/RNA, carbohydrates, etc.), enantiomeric compounds often display quite different biological activity. As a result, there is a need for the development of efficient methods for enantioselective organic synthesis. Transition metals catalyze a tremendous array of transformations, many of which cannot readily be accomplished by other types of catalysts. This research program focuses on the development of chiral ligands for transition metal-catalyzed processes. The investigation is comprised of two parts:  the synthesis of new families of ligands based on planar-chiral heterocycles.  the application of these new ligands to the development of highly enantioselective transition metal-catalyzed reactions.