DOES FSH SECRETE MORE IRREGULARLY THAN LH

最近引入的近似熵统计量(ApEn)具有 发现促黄体生成素和促卵泡刺激素的分泌谱有显著差异 在绵羊中，基于对五个受试者的初步研究，在患有FSH的妇女中 看起来比黄体生成素分泌得更不规律。这 来自美国国立卫生研究院的小企业创新研究资助将延长 在妇女中进行的试点研究，通过提供资金来研究改变的概况 另有5名女性接受了促黄体生成素和促卵泡激素治疗。这涉及到获取样本 五名妇女在2-5天内每7.5分钟采一次血，持续24小时 卵泡期的周期，并再次，一个月后没有 从黄体中期开始取样。这项研究将提供一个遥远的 更好的信息基线，可作为未来的参考 比较分泌物相对规律性差异的研究 这些促性腺激素在处于其他生命阶段或患有其他疾病的妇女中的表达 条件，例如围绝经期、绝经后、多囊性 卵巢综合征，伴有黄体短暂期缺陷，并伴有其他 生殖状态。近似值统计提供了完全不同的 补充通过传统技术获得的信息 脉搏分析。

The recently introduced approximate entropy statistic (ApEn) has revealed striking differences in the profiles of secretion of LH and FSH in sheep and, based on a pilot study of five subjects, in women with FSH appearing to be secreted in a far more irregular fashion than LH. This Small Business Innovative Research grant from the NIH will extend the pilot study in women by providing funding to study changing profiles of LH and FSH in an additional five women. This involves obtaining samples of blood every 7.5 min for 24 hrs from five women during days 2-5 of the follicular phase of their cycle and again, after a month with no sampling, from the mid-luteal phase. The study will provide a far better baseline of information that can serve as a reference for future studies comparing differences in relative regularity of the secretion of these gonadotropins in women in other stages of life or with other conditions, e.g. perimenopausal, post-menopausal, with polycystic ovarian syndrome, with short luteal phase defect, and with other reproductive states. The ApEn statistic provides completely different information complementing that obtained by conventional techniques of pulse analysis.