Low-Cost, High-Quality Prepolarized MRI Head Scanner

低成本、高质量预极化 MRI 头部扫描仪

• 批准号: 6660827
• 负责人: ALBERT MACOVSKI
• 金额: $ 36.08万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660827
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain imaging /visualization /scanning; clinical research; cost effectiveness; head; human subject; image enhancement; magnetic resonance imaging; phantom model

DESCRIPTION (provided by applicant): In May of 1999, we were awarded an R21 grant to study and develop a prototype hardware configuration for low-cost magnetic resonance imaging called Prepolarized MRI. During the R21 support, we succeeded in building a Prepolarized MRI scanner for less than $30,000 and we succeeded in acquiring in vivo human hand images. The image quality is roughly comparable to a 0.2 T conventional MRI scanner and is rapidly improving. This R33 application is in response to the Development of Novel Technologies for In Vivo Imaging (PAR-07- 707) Phased Innovation Initiative. Here we propose to extend the technology development initiated in the R21 grant to develop an ultra-low-cost prepolarized MRI head scanner. Prepolarized MRI uses two pulsed magnetic fields. First a strong but inhomogeneous polarizing magnet is pulsed on to polarize hydrogen. This field is turned off and a very low field MRI acquisition follows. A prepolarized MRI scanner with a 0.5 T polarizing field should obtain the image quality of a conventional 0.5 T MRI scanner for a small fraction of the capital cost of a conventional MRI scanner. Here we propose to build a 0.5 T polarizing magnet and a low-field imaging MRI scanner for head imaging. We also plan to develop all the standard imaging pulse sequences that are currently used for detecting and following brain tumors. We plan to investigate the new contrast mechanisms that prepolarized MRI can offer. And finally, we plan to do a small study comparing image quality on a conventional 0.5 T GE MRI scanner. The results of this study will provide feedback for optimizing both the hardware and pulse sequences.

描述（由申请人提供）： 1999年5月，我们获得了R21赠款，用于研究和开发原型 用于低成本磁共振成像的硬件配置， 预极化MRI。在R21支持期间，我们成功地构建了一个 预极化MRI扫描仪不到30，000美元，我们成功地获得了 活体人手图像。成像质量大致与0.2T相当 传统的MRI扫描仪，并正在迅速改善。此R33应用程序在 对体内成像新技术发展的回应（PAR-07- 707)分阶段创新。在这里，我们建议扩展技术， 在R21赠款中启动的开发，以开发超低成本 预极化核磁共振头部扫描仪 预极化MRI使用两个脉冲磁场。首先是一个强大的，但 不均匀的极化磁体被脉冲接通以吸收氢。这一领域 关闭，然后进行极低场MRI采集。预极化MRI 具有0.5T偏振场的扫描仪应获得 传统0.5 T MRI扫描仪的资本成本仅为设备的一小部分 常规MRI扫描仪。在这里我们提议建造一个0.5T的极化磁铁 以及用于头部成像的低场成像MRI扫描仪。我们还计划开发 当前用于检测的所有标准成像脉冲序列 以及脑瘤的治疗我们计划研究新的对比机制 所能提供的最佳效果最后，我们计划做一个小研究 比较传统0.5 T GE MRI扫描仪的图像质量。的结果 该研究将为优化硬件和脉冲提供反馈 序列的