Low-Cost, High-Quality Prepolarized MRI Head Scanner

低成本、高质量预极化 MRI 头部扫描仪

• 批准号: 6478568
• 负责人: ALBERT MACOVSKI
• 金额: $ 36.19万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478568
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain imaging /visualization /scanning; clinical research; cost effectiveness; head; human subject; image enhancement; magnetic resonance imaging; phantom model

DESCRIPTION (provided by applicant): In May of 1999, we were awarded an R21 grant to study and develop a prototype hardware configuration for low-cost magnetic resonance imaging called Prepolarized MRI. During the R21 support, we succeeded in building a Prepolarized MRI scanner for less than $30,000 and we succeeded in acquiring in vivo human hand images. The image quality is roughly comparable to a 0.2 T conventional MRI scanner and is rapidly improving. This R33 application is in response to the Development of Novel Technologies for In Vivo Imaging (PAR-07- 707) Phased Innovation Initiative. Here we propose to extend the technology development initiated in the R21 grant to develop an ultra-low-cost prepolarized MRI head scanner. Prepolarized MRI uses two pulsed magnetic fields. First a strong but inhomogeneous polarizing magnet is pulsed on to polarize hydrogen. This field is turned off and a very low field MRI acquisition follows. A prepolarized MRI scanner with a 0.5 T polarizing field should obtain the image quality of a conventional 0.5 T MRI scanner for a small fraction of the capital cost of a conventional MRI scanner. Here we propose to build a 0.5 T polarizing magnet and a low-field imaging MRI scanner for head imaging. We also plan to develop all the standard imaging pulse sequences that are currently used for detecting and following brain tumors. We plan to investigate the new contrast mechanisms that prepolarized MRI can offer. And finally, we plan to do a small study comparing image quality on a conventional 0.5 T GE MRI scanner. The results of this study will provide feedback for optimizing both the hardware and pulse sequences.

描述（由申请人提供）： 1999 年 5 月，我们获得了 R21 资助，用于研究和开发原型 低成本磁共振成像的硬件配置称为 预极化 MRI。在R21支持期间，我们成功构建了一个 预极化 MRI 扫描仪的价格不到 30,000 美元，我们成功获得 体内人手图像。图像质量大致相当于 0.2 T 传统的 MRI 扫描仪正在迅速改进。此 R33 应用程序位于 响应体内成像新技术的发展（PAR-07- 707) 分阶段创新计划。在这里我们建议扩展该技术 R21 拨款启动的开发旨在开发超低成本 预极化 MRI 头部扫描仪。 预极化 MRI 使用两个脉冲磁场。首先是强大但是 不均匀极化磁体被施加脉冲以极化氢。这个领域 关闭，随后进行极低场 MRI 采集。预极化 MRI 具有 0.5 T 偏振场的扫描仪应获得 传统 0.5 T MRI 扫描仪的资本成本只是 传统 MRI 扫描仪。这里我们建议建造一个0.5T的极化磁体 以及用于头部成像的低场成像 MRI 扫描仪。我们还计划开发 当前用于检测的所有标准成像脉冲序列 以及脑肿瘤之后。我们计划研究新的对比机制 预极化 MRI 可以提供的。最后，我们计划做一个小研究 比较传统 0.5 T GE MRI 扫描仪的图像质量。结果 这项研究将为优化硬件和脉冲提供反馈 序列。