Low-Cost, High-Quality Prepolarized MRI Head Scanner

低成本、高质量预极化 MRI 头部扫描仪

• 批准号: 6478568
• 负责人: ALBERT MACOVSKI
• 金额: $ 36.19万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478568
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain imaging /visualization /scanning; clinical research; cost effectiveness; head; human subject; image enhancement; magnetic resonance imaging; phantom model

DESCRIPTION (provided by applicant): In May of 1999, we were awarded an R21 grant to study and develop a prototype hardware configuration for low-cost magnetic resonance imaging called Prepolarized MRI. During the R21 support, we succeeded in building a Prepolarized MRI scanner for less than $30,000 and we succeeded in acquiring in vivo human hand images. The image quality is roughly comparable to a 0.2 T conventional MRI scanner and is rapidly improving. This R33 application is in response to the Development of Novel Technologies for In Vivo Imaging (PAR-07- 707) Phased Innovation Initiative. Here we propose to extend the technology development initiated in the R21 grant to develop an ultra-low-cost prepolarized MRI head scanner. Prepolarized MRI uses two pulsed magnetic fields. First a strong but inhomogeneous polarizing magnet is pulsed on to polarize hydrogen. This field is turned off and a very low field MRI acquisition follows. A prepolarized MRI scanner with a 0.5 T polarizing field should obtain the image quality of a conventional 0.5 T MRI scanner for a small fraction of the capital cost of a conventional MRI scanner. Here we propose to build a 0.5 T polarizing magnet and a low-field imaging MRI scanner for head imaging. We also plan to develop all the standard imaging pulse sequences that are currently used for detecting and following brain tumors. We plan to investigate the new contrast mechanisms that prepolarized MRI can offer. And finally, we plan to do a small study comparing image quality on a conventional 0.5 T GE MRI scanner. The results of this study will provide feedback for optimizing both the hardware and pulse sequences.

描述(由申请人提供)： 1999年5月，我们获得了R21资助，用于研究和开发样机 用于低成本磁共振成像的硬件配置称为 预极化核磁共振。在R21支持期间，我们成功构建了 预极化核磁共振扫描仪不到30,000美元，我们成功地获得了 活体人体手部图像。图像质量大致相当于0.2T 常规的核磁共振扫描仪正在迅速改进。此R33应用程序位于 对活体成像新技术发展的回应(PAR-07- 707)阶段性创新倡议。在这里，我们建议扩展这项技术 在R21赠款中启动的开发，以开发超低成本 预极化核磁共振头部扫描仪。 预极化核磁共振使用两个脉冲磁场。首先是一个强大的但 不均匀的极化磁铁被脉冲接通以极化氢。此字段 关闭，然后进行非常低场的磁共振成像采集。一种预极化磁共振成像 具有0.5T偏光场的扫描仪应获得 传统的0.5T核磁共振扫描仪只需一小部分资本成本 常规核磁共振扫描仪。在这里，我们建议建造一个0.5T的极化磁铁 以及一台低场成像核磁共振扫描仪，用于头部成像。我们还计划开发 当前用于检测的所有标准成像脉冲序列 以及脑瘤之后。我们计划研究新的对比剂机制 预极化核磁共振所能提供的。最后，我们计划做一个小研究 比较常规0.5T GE MRI扫描仪的图像质量。结果是 这项研究将为硬件和脉冲的优化提供反馈 序列。