Effects of manipulating germ cell niche in immature human testis: potential mechanism for protection from chemotherapy-induced damage

操纵未成熟人类睾丸生殖细胞生态位的影响：防止化疗引起损伤的潜在机制

• 批准号: 2141875
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2141875
• 关键词: Effects; manipulating; germ; cell; niche

Advanced development of chemotherapeutic drugs has increased the survival rates of childhood cancer patients to 80% (Mariotto et al. 2009). However, following treatment some male survivors willsubsequently become oligospermic or azoospermic, meaning that chances for these patients to father a child in the future are very reduced (Brook et al. 2001). Future fertility for these patients is of great concern and, although sperm cryopreservation for adults is well established, pre-pubertal boys or those who are not yet able to produce sperm are in need of options for fertility preservation (reviewed in Anderson et al. 2015).

化疗药物的先进开发使儿童癌症患者的生存率提高至80%（Mariotto et al. 2009）。然而，在治疗后，一些男性幸存者将随后成为少精症或无精症，这意味着这些患者未来生育孩子的机会非常减少（Brook et al. 2001）。这些患者的未来生育能力非常令人担忧，尽管成年人的精子冷冻保存已得到很好的建立，但青春期前男孩或尚不能产生精子的人需要选择生育能力保存（综述见安德森等人，2015）。

项目成果

The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty

• DOI: 10.1016/j.stem.2019.12.005
• 发表时间: 2020-02-06
• 期刊: CELL STEM CELL
• 影响因子: 23.9
• 作者: Guo, Jingtao;Nie, Xichen;Cairns, Bradley R.
• 通讯作者: Cairns, Bradley R.