Effects of manipulating germ cell niche in immature human testis: potential mechanism for protection from chemotherapy-induced damage

化疗药物的先进发展使儿童癌症患者的生存率提高到80% （Mariotto et al. 2009）。然而，在治疗之后，一些男性幸存者随后会变得少精子或无精子，这意味着这些患者将来生孩子的机会非常低（Brook et al. 2001）。这些患者的未来生育能力是非常值得关注的，尽管对成年人的精子冷冻保存已经建立起来，青春期前的男孩或那些还不能产生精子的人需要选择生育能力保存（见Anderson等人2015年的综述）。

Advanced development of chemotherapeutic drugs has increased the survival rates of childhood cancer patients to 80% (Mariotto et al. 2009). However, following treatment some male survivors willsubsequently become oligospermic or azoospermic, meaning that chances for these patients to father a child in the future are very reduced (Brook et al. 2001). Future fertility for these patients is of great concern and, although sperm cryopreservation for adults is well established, pre-pubertal boys or those who are not yet able to produce sperm are in need of options for fertility preservation (reviewed in Anderson et al. 2015).