HEALTH IMPROVEMENT & COST REDUCTION IN ANIMAL FACILITIES
健康改善
基本信息
- 批准号:6626153
- 负责人:
- 金额:$ 41.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-30 至 2005-03-31
- 项目状态:已结题
- 来源:
- 关键词:Helicobacter Mus musculus Pasteurella Pneumocystis carinii SCID mouse Staphylococcus aureus air filtration air sampling /monitoring airborne allergen ammonia animal care animal colony clinical research communicable disease control cost effectiveness enzyme linked immunosorbent assay epizootiology germ free condition human subject immediate hypersensitivity nonbiomedical equipment occupational disease /disorder occupational health /safety polymerase chain reaction tissue /cell culture work site
项目摘要
DESCRIPTION (Provided by applicant): The overall goal of the proposed studies
is to establish environmental conditions that optimize the health of mice used
in biomedical research, provide a safe and comfortable workplace, and minimize
the costs associated with doing animal-based research. The methods by which
the applicants will approach this goal include: (1) determining housing
conditions that minimize pathogen transfer, (2) evaluating effects of culling
on reproductive success, (3) identifying husbandry and hygiene practices that
reduce caretaker exposure to mouse allergen, and (4) instituting workplace
activities that may improve the health of animal caretakers. The
investigators will first study the capacity of ventilated caging maintained at
"neutral" airflow and negatively ventilated changing tables to reduce worker
exposure to allergen and to reduce or eliminate transfer of Pasteurella
pneumotropica, Helicobacter spp. and Pneumocystis carinii from infected mice
to pathogen-free immunocompromised mice. The applicants will determine
reproductive success of mice whose litters are culled or not and housed under
different ventilation conditions. The efficacy of water, dilute tannic acid,
and dilute sodium hypochlorite used to reduce breathing zone allergen levels
during bedding changes will be tested. Skin and clothing of caretakers will
be sampled for Staphylococcus aureus upon entry into mouse rooms through air
or wet showers and for allergen upon exiting the facility through air or wet
showers. In an effort to reduce employee workplace injuries, a functional
capacity checklist will be developed and will be used to design an employee
exercise program. Lastly, a pre-employment Functional Capacity Assessment
tool to help slot new hires in positions for which they are physically capable
will be used.
描述(由申请方提供):拟定研究的总体目标
是建立优化小鼠健康的环境条件,
在生物医学研究中,提供安全舒适的工作场所,
与动物研究相关的成本。 的手段
申请人将实现这一目标包括:(1)确定住房
最大限度地减少病原体转移的条件,(2)评估淘汰的效果
(3)确定畜牧业和卫生习惯,
减少看护人接触小鼠过敏原,以及(4)建立工作场所
可以改善动物护理人员健康的活动。 的
研究人员将首先研究通风笼的容量,
“中性”气流和负通风换台,减少工人
暴露于过敏原并减少或消除巴氏杆菌的转移
嗜肺菌、螺杆菌属(Helicobacter spp.)和卡氏肺孢子虫
无病原体的免疫缺陷小鼠。 申请人将决定
小鼠的繁殖成功率,其窝仔被剔除或不被剔除,
不同的通风条件。 水的功效,稀释单宁酸,
和稀释次氯酸钠用于降低呼吸区过敏原水平
在床上的变化将进行测试。 看护人的皮肤和衣服
通过空气进入小鼠房间后,对金黄色葡萄球菌进行采样
或湿淋浴和过敏原离开设施后,通过空气或湿
淋浴。 为了减少员工的工伤事故,
将制定能力检查表,并将其用于设计员工
锻炼计划。 最后,就业前职能能力评估
这是一个帮助新员工在他们有能力胜任的岗位上工作的工具
将用于
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ABIGAIL L SMITH其他文献
ABIGAIL L SMITH的其他文献
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{{ truncateString('ABIGAIL L SMITH', 18)}}的其他基金
CONTROLLING ALLERGENS AND COSTS IN THE ANIMAL FACILITY
控制动物设施中的过敏原和成本
- 批准号:
6188580 - 财政年份:1998
- 资助金额:
$ 41.18万 - 项目类别:
HEALTH IMPROVEMENT & COST REDUCTION IN ANIMAL FACILITIES
健康改善
- 批准号:
6487045 - 财政年份:1998
- 资助金额:
$ 41.18万 - 项目类别:
NEWLY RECOGNIZED LYMPHOCYTOTROPIC PARVOVIRUS OF MICE
新发现的小鼠嗜淋巴细胞细小病毒
- 批准号:
2285845 - 财政年份:1995
- 资助金额:
$ 41.18万 - 项目类别:
A NEWLY RECOGNIZED LYMPHOCYTOTROPIC PARVOVIRUS OF MICE
新发现的小鼠嗜淋巴细胞细小病毒
- 批准号:
2669135 - 财政年份:1995
- 资助金额:
$ 41.18万 - 项目类别:
NEWLY RECOGNIZED LYMPHOCYTOTROPIC PARVOVIRUS OF MICE
新发现的小鼠嗜淋巴细胞细小病毒
- 批准号:
2285846 - 财政年份:1995
- 资助金额:
$ 41.18万 - 项目类别:
A NEWLY RECOGNIZED LYMPHOCYTOTROPIC PARVOVIRUS OF MICE
新发现的小鼠嗜淋巴细胞细小病毒
- 批准号:
2379975 - 财政年份:1995
- 资助金额:
$ 41.18万 - 项目类别:
MOUSE HEPATITIS VIRUS-ASSOCIATED IMMUNE DYSFUNCTION
小鼠肝炎病毒相关的免疫功能障碍
- 批准号:
3451117 - 财政年份:1988
- 资助金额:
$ 41.18万 - 项目类别:
MOUSE HEPATITIS VIRUS-ASSOCIATED IMMUNE DYSFUNCTION
小鼠肝炎病毒相关的免疫功能障碍
- 批准号:
2282924 - 财政年份:1988
- 资助金额:
$ 41.18万 - 项目类别:
MOUSE HEPATITIS VIRUS-ASSOCIATED IMMUNE DYSFUNCTION
小鼠肝炎病毒相关的免疫功能障碍
- 批准号:
3451120 - 财政年份:1988
- 资助金额:
$ 41.18万 - 项目类别:
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