TREATMENT PREFERENCE AND VEGETARIAN DIET IN WEIGHT LOSS

描述：（改编自研究者摘要）肥胖，一种慢性疾病 影响美国三分之一的成年人口，是第二大原因。 是可预防死亡的主要原因，也是医疗保健费用增加的主要原因。 即使是适度的减肥也可以改善并发症并延长寿命。 虽然行为减肥在短期内取得了很好的成功， 其次是极高的再犯率 本研究的主要目的是促进长期减肥， 专注于使用乳蛋素食（LOV）饮食计划作为膳食 战略，以及治疗偏好的作用。临床研究表明 素食饮食计划可以持续一段时间， 产生显著和持续的减肥以及许多健康 效益试点数据显示，素食计划导致可接受的体重 损失也有证据表明，使用治疗偏好会导致 以改善粘附性和减少磨损。拟议的研究将测试， 给予参与者他们的偏好导致更好的坚持，减少 磨损，改善长期减肥。优先级将与2交叉 治疗选择：标准行为治疗和标准行为治疗 治疗+乳蛋素食计划（SBT + LOV）。参与者（n=168） 将被随机分配至2个条件之一：治疗偏好-是或否。 偏好-是范围内的个体将被分配到其治疗选择 (SBT或SBT + LOV），则偏好-否中的受试者将随机分配至1或2组 处理条件：SBT或SBT + LOV。所有受试者将接受治疗 持续12个月，并将在基线、6、12和18个月时完成评估。 主要目的是检验治疗分配与 治疗偏好及其对主要结局的影响， 基线至18个月。次要结局包括依从性和血脂。 这项研究代表了一个严重问题的创新方法， 保持长期减肥。它将提供有关 素食计划在治疗肥胖症方面的功效， 解决素食研究的批评，这些研究表明， 自我选择是他们报告的成功结果的一个关键因素。 此外，该研究将提供有关治疗作用的信息， 偏好，其对行为和临床结果的影响，以及参与者的 治疗偏好的特点。

DESCRIPTION: (adapted from Investigator's abstract) Obesity, a chronic disorder affecting one third of the U.S. adult population, is the second leading cause of preventable death and a major contributor to increased health care costs. Even a modest weight loss can ameliorate complications and improve longevity. Although behavioral weight loss results in good short-term success, it is followed by an extremely high rate of recidivism. The primary aim of the present study is to promote long-term weight loss by focusing on the use of a lacto-ovo-vegetarian (LOV) eating plan as a dietary strategy, and also on the role of treatment preference. Clinical studies show that vegetarian eating plans can be followed for sustained periods and can produce significant and sustained weight loss as well as numerous health benefits. Pilot data showed that a vegetarian plan leads to acceptable weight loss. There is also evidence to suggest that use of treatment preference leads to improved adherence and reduced attrition. The proposed study will test if giving participants their preference leads to improved adherence, reduced attrition, improved long-term weight loss. Preference will be crossed with 2 treatment options: standard behavioral treatment and standard behavioral treatment + lacto-ovo-vegetarian eating plan (SBT + LOV). Participants (n=168) will be randomized to 1 of 2 conditions: Treatment Preference - Yes or No. Individuals within Preference-Yes will be assigned to their treatment choice (SBT or SBT + LOV), those in Preference-No will be randomized to 1 or the 2 treatment conditions : SBT or SBT + LOV. All subjects will receive treatment for 12 months and will complete assessments at baseline, 6, 12, and 18 months. The primary aim will test the interaction between treatment assignment and treatment preference and its effect on the primary outcome, weight change from baseline to 18 months. Secondary outcomes include adherence and serum lipids. This study represents an innovative approach to a serious issue, the failure to maintain long-term weight loss. It will provide important information about the efficacy of a vegetarian eating plan in the treatment of obesity, and will address the criticism of vegetarian studies that suggest that patient self-selection is a critical factor in their reported successful outcomes. Additionally, the study will provide information on the role of treatment preference, its effect on behavioral and clinical outcomes, and participants' characteristics by treatment preference.