TREATMENT PREFERENCE AND VEGETARIAN DIET IN WEIGHT LOSS

减肥中的治疗偏好和素食

• 批准号: 6730511
• 负责人: LORA Emilie BURKE
• 金额: $ 31.4万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6730511
• 关键词: alternative medicine; behavior therapy; behavioral /social science research tag; clinical research; diet therapy; human subject; human therapy evaluation; nutrition related tag; obesity; patient oriented research; preference; therapy compliance; vegetarian diet; weight loss

DESCRIPTION: (adapted from Investigator's abstract) Obesity, a chronic disorder affecting one third of the U.S. adult population, is the second leading cause of preventable death and a major contributor to increased health care costs. Even a modest weight loss can ameliorate complications and improve longevity. Although behavioral weight loss results in good short-term success, it is followed by an extremely high rate of recidivism. The primary aim of the present study is to promote long-term weight loss by focusing on the use of a lacto-ovo-vegetarian (LOV) eating plan as a dietary strategy, and also on the role of treatment preference. Clinical studies show that vegetarian eating plans can be followed for sustained periods and can produce significant and sustained weight loss as well as numerous health benefits. Pilot data showed that a vegetarian plan leads to acceptable weight loss. There is also evidence to suggest that use of treatment preference leads to improved adherence and reduced attrition. The proposed study will test if giving participants their preference leads to improved adherence, reduced attrition, improved long-term weight loss. Preference will be crossed with 2 treatment options: standard behavioral treatment and standard behavioral treatment + lacto-ovo-vegetarian eating plan (SBT + LOV). Participants (n=168) will be randomized to 1 of 2 conditions: Treatment Preference - Yes or No. Individuals within Preference-Yes will be assigned to their treatment choice (SBT or SBT + LOV), those in Preference-No will be randomized to 1 or the 2 treatment conditions : SBT or SBT + LOV. All subjects will receive treatment for 12 months and will complete assessments at baseline, 6, 12, and 18 months. The primary aim will test the interaction between treatment assignment and treatment preference and its effect on the primary outcome, weight change from baseline to 18 months. Secondary outcomes include adherence and serum lipids. This study represents an innovative approach to a serious issue, the failure to maintain long-term weight loss. It will provide important information about the efficacy of a vegetarian eating plan in the treatment of obesity, and will address the criticism of vegetarian studies that suggest that patient self-selection is a critical factor in their reported successful outcomes. Additionally, the study will provide information on the role of treatment preference, its effect on behavioral and clinical outcomes, and participants' characteristics by treatment preference.

描述：(改编自调查者摘要)肥胖，一种慢性疾病 影响三分之一的美国成年人口，是第二大原因 这是可预防死亡的主要原因，也是卫生保健费用增加的主要原因。 即使是适度的减肥也可以减少并发症，延长寿命。 虽然行为减肥会带来短期的成功，但事实并非如此 其次是极高的累犯率。 本研究的主要目的是通过以下方式促进长期减肥 重点是使用乳蛋素食(LOV)作为饮食计划 战略，也就是治疗偏好的作用。临床研究表明 素食计划可以持续一段时间，而且可以 产生显著和持续的体重减轻以及大量的健康 福利。试点数据显示，素食计划可以产生可接受的体重。 损失。也有证据表明，使用治疗偏好会导致 提高了粘附性，减少了磨损。拟议的研究将测试是否 给予参与者他们的偏好会导致更高的忠诚度，减少 减重，改善长期减肥效果。优先选项将与%2交叉 治疗选择：标准行为治疗和标准行为治疗 治疗+乳蛋素食计划(SBT+LOV)。参与者(n=168) 将随机分为两种情况中的一种：治疗偏好-是或否。 首选范围内的个人-是将分配给他们的治疗选择 (SBT或SBT+LOV)，优先-否的将随机到1或2 治疗条件：SBT或SBT+LOV。所有受试者都将接受治疗 为期12个月，将在基线、6个月、12个月和18个月完成评估。 主要目的是测试治疗分配和治疗之间的相互作用 治疗偏好及其对主要结局、体重变化的影响 基线为18个月。次要结果包括依从性和血脂。 这项研究代表了一个严重问题的创新方法，即未能 保持长期减肥。它将提供有关 素食计划在治疗肥胖症方面的有效性，并将 回应对素食研究的批评，认为患者 自我选择是他们所报告的成功结果的关键因素。 此外，该研究还将提供有关治疗作用的信息 偏好，它对行为和临床结果的影响，以及参与者的 按治疗偏好分类的特征。