Declarative and Emotional Memory in Alzheimer's disease

阿尔茨海默病的陈述性记忆和情绪性记忆

• 批准号: 6625706
• 负责人: PAULINE F MCHUGH
• 金额: $ 14.42万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-15 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6625706
• 关键词: Alzheimer's disease; age difference; amygdala; behavioral /social science research tag; brain imaging /visualization /scanning; brain morphology; cingulate gyrus; clinical research; emotions; frontal lobe /cortex; gender difference; hippocampus; human old age (65+); human subject; limbic system; magnetic resonance imaging; memory; neural information processing; neuroanatomy; neurophysiology; neuropsychological tests; pathologic process; psychological aspect of aging; psychometrics; young adult human (21-34)

DESCRIPTION (provided by applicant): While much is known about the cognitive deterioration that occurs in Alzheimer's Disease (AD), less is known about the effects of AD pathology on the emotional systems in the brain. Damage to the mediotemporal lobe (MTL) occurs early in AD, and damage to the hippocampal formation within the MTL has been very closely linked with the decline in declarative memory that is often one of the first symptoms of AD. The hippocampal formation is interconnected with the amygdala, an MTL limbic brain structure believed to be involved in a number of emotional processing functions, including the enhancement of memory by emotional content, the discrimination of odors, and fear conditioning. The amygdala also is damaged very early in the course of AD, but the effects of this damage, as well as its relationship to damage in the hippocampal formation, are not well understood. We propose to conduct a cross-sectional study to evaluate the relative structural and functional status of these two systems in the earliest stages of AD. The specific aims of this study are to contrast MRI-derived volumes of neural structures involved in declarative memory (hippocampal formation) with those of neural structures involved in emotional processing (amygdala, orbitofrontal region, and anterior cingulate gyrus) in participants with mild AD, mild cognitive impairment (MCI, a group known to be at high risk for AD), and normal age- and gender-matched controls. We also will use various pertinent neuropsychological and psychometric tests to assess the functional status of these two neural systems in the three groups of subjects. Research participants will include a total of 90 elderly individuals between 60 to 75 years of age and 50 percent female, consisting of 30 elderly individuals in each of the three groups. In addition, 30 young normal individuals between 18 to 30 years of age, and 50 percent female will be included to study the effects of age and age-by-gender interactions on the systems under study. With this research, we hope to better understand the effects of early AD pathology on specific amygdala and emotional brain functions in order to help clarify the diagnosis of early AD, as well as to form the basis for future longitudinal studies of emotional brain function in AD.

描述（由申请人提供）：虽然对认知知之甚少 阿尔茨海默氏病（AD）发生的恶化，对 AD病理对大脑情绪系统的影响。损坏 中颞叶（MTL）发生在AD的早期，并损坏海马 MTL内的形成与下降密切相关 声明性记忆通常是AD的第一个症状之一。这 海马形成与MTL边缘大脑的杏仁核相互连接 被认为参与许多情感处理的结构 功能，包括通过情感内容增强记忆的功能， 歧视气味和恐惧条件。杏仁核也损坏了 在广告过程的早期，但是这种损害的影响及其 在海马形成中与损伤的关系尚不清楚。 我们建议进行横断面研究以评估相对 最早的这两个系统的结构和功能状态 广告。这项研究的具体目的是对比MRI衍生的体积 与声明性记忆（海马形成）有关的神经结构与 与情感处理有关的神经结构的那些（Amygdala， 轻度参与者的眶额区域和前扣带回回 AD，轻度认知障碍（MCI，一个已知AD高风险的群体）， 以及正常的年龄和性别匹配的对照。我们还将使用各种 相关的神经心理学和心理测试测试以评估功能 这两个神经系统在三组受试者中的状态。研究 参与者将包括60至75岁之间的90名老年人 年龄和50％的女性，由30个老年人组成 三组中的每一个。此外，在18岁之间有30个年轻人 到30岁，将包括50％的女性来研究 年龄和年龄相互作用对正在研究的系统的影响。和 这项研究，我们希望更好地了解早期AD病理的影响 在特定的杏仁核和情感大脑功能上，以帮助澄清 早期AD的诊断，并构成未来的基础 AD中情绪大脑功能的纵向研究。