New Model for Assessing Cartilage Repair and Protection

描述（由申请人提供）：各种形式，范围从 软骨移植到药物中，已经证明了相当大的希望， 作为改变骨关节炎进展的方法。这导致 对评估早期骨关节炎软骨的方法的兴趣增加 人类和动物的变化。这项建议的目的是 改进目前的动物模型，用于评估治疗方法， 治疗骨关节炎软骨。 具体来说，这项工作的假设是，光学相干层析成像， (OCT)当联合收割机与兔和大鼠骨关节炎模型结合时， 显示出用于评价潜在治疗剂的独特优势。 该计划是正在进行的合作的延续， 布里格姆妇女医院和国王学院的调查人员。是 假设所提出的模型，除了增加信息， 治疗的功效，将减少需要被治疗的动物的数量。 牺牲，需要处理的组织的量，以及 需要治疗。此外，技术进步可以直接 转移到人体内应用。该提案的假设将 通过技术开发和动物研究进行测试。细节 目标是：目标1。为了构建一个恒速偏振旋转器， OCT系统。目标二。开发一种能够进入 用20号针头缝合瞄准3.为了验证注册的 关节镜系统。目标4。OCT系统将在兔子身上进行测试 模型目标5。将开发导管以在大鼠模型中成像。目标6。的 将在大鼠模型中测试OCT成像导管。

DESCRIPTION (Provided by Applicant): A variety of modalities, ranging from cartilage transplant to pharmaceuticals, have demonstrated considerable promise as methods for altering the progression of osteoarthritis. This has resulted in heightened interest in methods for assessing early osteoarthritic cartilage changes both in humans and animals. The objective of this proposal is to improve current animal models for the evaluation of therapeutics designed to treat osteoarthritic cartilage. Specifically, the hypothesis of this work is that Optical Coherence Tomography (OCT), when combine with rabbit and rat models of osteoarthritis, will demonstrate unique advantages for the evaluation of potential therapeutics. This program is a continuation of an ongoing collaboration between investigators at Brigham and Women's Hospital and King's College. It is postulated that the proposed model, in addition to increasing information on the efficacy of therapeutics, will reduce the number of animals that need to be sacrificed, the quantity of tissue requiring processing, and the amount of therapeutics required. Furthermore, technological advances can be directly transferred to in vivo human applications. The hypothesis of this proposal will be tested both through technology development and animal studies. The specifics aims are: Aim 1. To construct a constant velocity polarization rotator for the OCT system. Aim 2. To development an OCT arthroscope capable of accessing a joint through a 20 gauge needle. Aim. 3. To validate registration of the arthroscopic based system. Aim 4. The OCT system will be tested in a rabbit model. Aim 5. A catheter will be developed to image in a rat model. Aim 6. The OCT imaging catheter will be tested in a rat model.