Optical Coherence Tomography for Microsurgical Guidance

用于显微外科手术指导的光学相干断层扫描

• 批准号: 6893664
• 负责人: Mark E Brezinski
• 金额: $ 31.52万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6893664
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; blood vessels; human tissue; laboratory rat; microsurgery; nerve injury; neuroimaging; neurosurgery; optical tomography; technology /technique development

Nerve and small vessel repair are important, widely used medical techniques. Current technologies do not allow imaging to be performed below the tissue surface, so that the alignment of fascicles or vessel layers can not be established. Misalignment is one of the major reasons that the results of nerve repair are currently poor. Similarly, with small vessel repair, intimal flap and adventitial inversions, which can not be detected from the surface, can lead to subacute vascular occlusion. Optical coherence tomography (OCT) is a recently developed high resolution imaging modality. OCT is analogous to ultrasound, measuring the intensity of backreflected infrared light rather than sound. The resolution of OCT is between 2-20 mum, up to 25X higher than anything available in clinical medicine. In addition to it's high resolution, advantages of OCT include its high data acquisition rate, compact portable size, the small inexpensive probes, and the ability to be combine with various forms of spectroscopy. The hypothesis of this work is that OCT can be used to improve the outcome of nerve and small vessel repair. The hypothesis will be tested with the following specific aims: 1. Develop a clinically viable hand held probe, 2. Development of an all digital Doppler system, 3. Investigate structural and Doppler OCT for vascular repair in vitro, 4. Investigate structural and Doppler OCT for vascular repair in vivo, 5. Perform studies comparing OCT and Conventional surgical microscopy in vivo, 6. Use structural, polarization, and spectroscopic data to identify sensor vs motor nerves, and 7. guide epineural nerve repair with OCT guidance.

神经和小血管修复是重要且广泛使用的医疗技术。 目前的技术不允许在组织表面以下进行成像，因此无法建立束或血管层的对齐。 错位是目前神经修复效果不佳的主要原因之一。 同样，通过小血管修复，无法从表面检测到的内膜瓣和外膜倒转可导致亚急性血管闭塞。 光学相干断层扫描（OCT）是最近开发的高分辨率成像模式。 OCT 类似于超声波，测量背反射红外光而不是声音的强度。 OCT 的分辨率在 2-20 微米之间，比临床医学中可用的任何分辨率高出 25 倍。 除了高分辨率之外，OCT 的优点还包括高数据采集速率、紧凑的便携式尺寸、小型廉价探头以及与各种形式的光谱学结合的能力。 这项工作的假设是 OCT 可用于改善神经和小血管修复的结果。该假设将通过以下具体目标进行测试： 1. 开发临床上可行的手持式探头， 2. 开发全数字多普勒系统， 3. 研究体外血管修复的结构和多普勒 OCT， 4. 研究体内血管修复的结构和多普勒 OCT，5. 进行体内 OCT 和传统手术显微镜的比较研究，6. 使用结构、偏振和光谱 数据来识别传感器神经与运动神经，7. 通过 OCT 引导指导神经外神经修复。