A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS

描述：（由申请人提供）慢性病的发病率各不相同 美国印第安人和阿拉斯加原住民（AIANs）和美国 白色人口的原因在很大程度上是未知的。虽然很少 了解影响AIAN慢性病的因素， 大多数慢性病都在增加。这四年计划的重点是 发展一个AIAN队列，以更好地了解 AIAN之间存在的疾病率和风险因素知识的差异 和美国的白色人口。本提案的目的是制定有效的 和可靠的方法来获得饮食，体力活动和生活方式 信息，并确定最有效率和最有效的招聘方式， 招募并跟踪来自不同人群的研究参与者。我们将 与当地社区合作，制定文化上适当的问卷， 将准确捕捉饮食摄入量，身体活动模式，生活方式 文化习惯。我们将与当地的医疗服务提供者和印第安人合作， 卫生服务部门从病历中获取相关研究相关数据， 我们将建立基于人口的招聘方法。从第三年开始， 建议，我们将启动招募和数据收集，测试， 各种协议，以确定最有效的方式进行 书房我们预计2000名阿拉斯加原住民，3000名美洲印第安人， 纳瓦霍族和1500名来自平原州的美国印第安人将在 在24个月的时间内注册。需要这一数量的参与者， 充分测试我们招募大量个人的能力， 确定因入组而对诊所造成的潜在负担。主要 AIAN队列的科学目标是确定饮食，身体 活动，以及其他生活方式和文化因素与发展 和慢性疾病如癌症，心血管疾病， 中风、2型糖尿病、慢性肺部和呼吸系统疾病及相关疾病 这些疾病的死亡率。研究数据将用于评估健康状况 并确定面临各种健康状况风险的人口群体。 纵向数据将用于确定有助于健康的因素 预防疾病。AIAN队列将作为一种资源， 对健康感兴趣的AIAN学生的研究和培训活动 研究、健康教育和一般公共卫生。

DESCRIPTION: (Provided by applicant) Rates of chronic diseases vary substantially between American Indians and Alaska Natives (AIANs) and U.S. white populations for reasons that are largely unknown. Although little is known about factors that affect chronic diseases in AIANs, incidence rates for most chronic diseases are increasing. This 4-year proposal focuses on the development of an AIAN cohort to obtain a better understanding of the disparity in disease rates and risk factor knowledge that exist between AIANs and U.S. white populations. The purpose of this proposal is to develop valid and reliable methods to obtain diet, physical activity, and lifestyle information and to determine the most efficient and effective ways to recruit, enroll, and track study participants from diverse populations. We will work with local communities to develop culturally appropriate questionnaires that will accurately capture dietary intake, physical activity patterns lifestyle and cultural habits. We will work with local health providers and the Indian Health Service to access relevant study-related data from medical records and we will establish population-based recruitment methods. Starting in year 3 of the proposal, we will initiate recruitment and data collection, testing various protocols to determine the most efficient and effective way to conduct the study. We project that 2000 Alaska Natives, 3000 American Indians from the Navajo Nation, and 1500 American Indians from the Plains states will be enrolled over a 24-month time period. This number of participants is needed to adequately test our ability to enroll large numbers of individuals as well as determine potential burden to clinics as a result of enrollment. The major scientific goal of the AIAN cohort is to determine how diet, physical activity, and other lifestyle and cultural factors relate to the development and progression of chronic diseases such as cancer, cardiovascular disease, stroke, Type 2 diabetes, chronic lung and respiratory diseases, and related mortality from these diseases. Study data will be used to assess health status and identify groups of the population at risk for various health conditions. Longitudinal data will be used to identify factors that contribute to health and prevent disease. The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health.