Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women

描述（由申请方提供）：西班牙裔和非西班牙裔白色（NHW）女性之间的乳腺癌发病率差异超过2倍;西班牙裔女性诊断后的生存率低于NHW女性。我们建议评估这些健康的差距，乳腺癌的发展和生存沿着继续美国印第安人NHW妇女利用现有的资源，从4角的国家，加州，墨西哥城。利用的现有资源将是行为和社会生活方式暴露数据沿着访谈时获得的DNA。生存数据正在进行中，并将继续通过当地SEER和CDC肿瘤登记研究进行监测。遗传和生活方式数据可从大约8039例西班牙裔和NHW乳腺癌病例和基于人群的对照中获得。通过汇集三项研究的资源，我们将有效地研究一种生物学途径，我们认为这种途径对乳腺癌的发展和生存很重要，并影响西班牙裔和NHW女性乳腺癌发病率的差异。遗传因素的评估将集中在一个途径，似乎与胰岛素，雌激素和炎症相关的途径，并代表了一个汇合点。我们称之为激素、炎症和能量功能会聚（CHIEF）信号通路的这一通路尚未在西班牙裔或非西班牙裔白色女性中进行全面研究，将包括待研究的基因，包括SOC 1、SOC 2、AKT、FRAP 1（别名mTOR）、P13K、STK11、AMP、PTEN、VEGF和S6K1、S6K2、CRP、NF κ B、IKB、IL10、IL8、IL6、TNF α。将在西班牙裔和NHW女性中检测这些基因的遗传多态性和单倍型之间以及美洲印第安血统的比例之间的乳腺癌关联。将检查信号通路基因彼此之间以及与NSAID、阿司匹林、BMI、雌激素和体力活动的相互作用。这些遗传因素将与生存率一起进行评估，以确定其对西班牙裔和NHW女性中观察到的生存差异的贡献。公共卫生相关性：这项研究将促进我们对西班牙裔和美洲印第安妇女以及整体妇女乳腺癌病因的理解。高风险人群和低风险人群之间的对比将以具有成本效益的方式加强这一努力。结果可以确定药物治疗的潜在靶点。

DESCRIPTION (provided by applicant): The incidence rates of breast cancer vary more than two-fold between Hispanic and non-Hispanic white (NHW) women; Hispanic women have worse survival after diagnosis than NHW women. We propose to evaluate these health disparities in breast cancer development and survival along the continuation of American Indian to NHW women utilizing existing resources from the 4 Corner's States, California, and Mexico City. Existing resources utilized will be behavioral and social lifestyle exposure data along with DNA obtained at the time of interview. Survival data has been ongoing and will continue to be monitored via local SEER and CDC tumor registries. Genetic and lifestyle data are available from approximately 8039 Hispanic and NHW cases of breast cancer and population-based controls. By pooling resources from three studies, we will efficiently examine a biological pathway that we believe is important to breast cancer development and survival and that influences differences in breast cancer rates among Hispanic and NHW women. Evaluation of genetic factors will focus on a pathway that appears to work in conjunction with insulin-, estrogen-, and inflammation-related pathways and represents a point of convergence. This pathway, which we call the Convergence of Hormones, Inflammation, and Energy Functioning (CHIEF) Signaling Pathway has not been studied comprehensively in either Hispanic or non-Hispanic white women and will include genes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, & S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform. Breast cancer associations will be tested between genetic polymorphisms and haplotypes of these genes in Hispanic and NHW women and by proportion of American Indian ancestry. Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined. These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women. PUBLIC HEALTH RELEVANCE: This study will advance our understanding of breast cancer etiology in Hispanic and American Indian women as well as women overall. The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy.