Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women

乳腺癌的差异：西班牙裔和 NHW 女性的发展和生存

• 批准号: 8017873
• 负责人: Martha L SLATTERY
• 金额: $ 91.19万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8017873
• 关键词: Development; Hispanics; Woman; malignant breast neoplasm

DESCRIPTION (provided by applicant): The incidence rates of breast cancer vary more than two-fold between Hispanic and non-Hispanic white (NHW) women; Hispanic women have worse survival after diagnosis than NHW women. We propose to evaluate these health disparities in breast cancer development and survival along the continuation of American Indian to NHW women utilizing existing resources from the 4 Corner's States, California, and Mexico City. Existing resources utilized will be behavioral and social lifestyle exposure data along with DNA obtained at the time of interview. Survival data has been ongoing and will continue to be monitored via local SEER and CDC tumor registries. Genetic and lifestyle data are available from approximately 8039 Hispanic and NHW cases of breast cancer and population-based controls. By pooling resources from three studies, we will efficiently examine a biological pathway that we believe is important to breast cancer development and survival and that influences differences in breast cancer rates among Hispanic and NHW women. Evaluation of genetic factors will focus on a pathway that appears to work in conjunction with insulin-, estrogen-, and inflammation-related pathways and represents a point of convergence. This pathway, which we call the Convergence of Hormones, Inflammation, and Energy Functioning (CHIEF) Signaling Pathway has not been studied comprehensively in either Hispanic or non-Hispanic white women and will include genes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, & S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform. Breast cancer associations will be tested between genetic polymorphisms and haplotypes of these genes in Hispanic and NHW women and by proportion of American Indian ancestry. Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined. These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women. PUBLIC HEALTH RELEVANCE: This study will advance our understanding of breast cancer etiology in Hispanic and American Indian women as well as women overall. The contrast between high and low risk populations will enhance this effort in a cost-efficient manner. Results could identify potential targets for drug therapy.

描述（由申请人提供）：西班牙裔和非西班牙裔白人 (NHW) 女性的乳腺癌发病率相差两倍以上；西班牙裔女性诊断后的生存率比 NHW 女性更差。我们建议利用来自四个角州、加利福尼亚州和墨西哥城的现有资源，评估从美洲印第安人到 NHW 妇女的延续过程中乳腺癌发展和生存方面的健康差异。现有资源将包括行为和社会生活方式暴露数据以及访谈时获得的 DNA。生存数据一直在进行中，并将继续通过当地 SEER 和 CDC 肿瘤登记处进行监测。遗传和生活方式数据来自约 8039 例西班牙裔和 NHW 乳腺癌病例以及基于人群的对照。通过汇集三项研究的资源，我们将有效地研究一种生物学途径，我们认为该途径对乳腺癌的发展和生存很重要，并且会影响西班牙裔和非白人女性乳腺癌发病率的差异。对遗传因素的评估将集中于似乎与胰岛素、雌激素和炎症相关途径协同作用并代表聚合点的途径。该通路，我们称之为激素、炎症和能量功能聚合 (CHIEF) 信号通路，尚未在西班牙裔或非西班牙裔白人女性中进行全面研究，并且将包括待研究的基因，包括 SOC1、SOC2、AKT、FRAP1（别名 mTOR）、P13K、STK11、AMP、PTEN、VEGF 和 S6K1、S6K2、反应蛋白， 使用 Illumina 平台的 NFKB、IKB、IL10、IL8、IL6、TNFalpha。将在西班牙裔和 NHW 女性中以及美洲印第安人血统的比例中测试这些基因的遗传多态性和单倍型之间的乳腺癌关联。将检查信号通路基因之间以及与非甾体抗炎药、阿司匹林、体重指数、雌激素和体力活动之间的相互作用。这些遗传因素将通过生存率进行评估，以确定它们对西班牙裔和 NHW 女性生存差异的影响。公共卫生相关性：这项研究将增进我们对西班牙裔和美洲印第安人女性以及整体女性乳腺癌病因的了解。高风险人群和低风险人群之间的对比将以具有成本效益的方式加强这项工作。结果可以确定药物治疗的潜在靶点。