Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women

乳腺癌的差异：西班牙裔和 NHW 女性的发展和生存

• 批准号: 8540349
• 负责人: Martha L SLATTERY
• 金额: $ 55.99万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540349
• 关键词: AKT1 gene; Admixture; Affect; Age; American Indians; Androgens; Apoptosis; Applications Grants; Area; Arizona; Aspirin; Behavioral; Biological; Body Weight Changes; Body mass index; Breast; Breast Cancer Genetics; Breast Cancer Risk Factor; California; Cancer Etiology; Candidate Disease Gene; Case-Control Studies; Centers for Disease Control and Prevention (U.S.); Characteristics; Cities; Colorado; Complex; DNA; Data; Development; Diagnosis; Diet; Disease; ESR1 gene; ESR2 gene; Epidemiology; Estrogen Receptor Status; Estrogen receptor negative; Estrogens; Ethnic Origin; Etiology; European; Evaluation; FRAP1 gene; Gene Frequency; Genes; Genetic; Genetic Polymorphism; Genetic Transcription; Genetic Variation; Genotype; Goals; Growth Factor; Haplotypes; Hispanics; Hormonal; Hormone replacement therapy; Hormones; I-kappa B Proteins; IGF1 gene; IGFBP3 gene; IL4 gene; IL6 gene; IL8 gene; IRS1 gene; Ibuprofen; Incidence; Inflammation; Insulin; Interleukin-1; Interleukin-10; Interview; Life; Life Style; Menopausal Status; Mexico; Modeling; Monitor; NF-kappa B; Native Americans; Native-Born; New Mexico; Non-Steroidal Anti-Inflammatory Agents; Not Hispanic or Latino; Obesity; Oranges; PTEN gene; Pathway interactions; Patient Self-Report; Pharmaceutical Preparations; Pharmacotherapy; Physical activity; Population; Population Study; Principal Investigator; Proteins; Proto-Oncogene Proteins c-akt; Race; Regulation; Relative Risks; Reproductive History; Research; Resources; Risk; Risk Factors; Role; SHBG gene; STAT1 gene; STAT6 gene; STK11 gene; San Francisco; Signal Pathway; Signal Transduction; Signaling Pathway Gene; Somatotropin; Southwestern United States; Stage at Diagnosis; TNF gene; TSC1 gene; Testing; Time; United States; Utah; Vascular Endothelial Growth Factors; Woman; Work; breast cancer diagnosis; cancer risk; cell growth; cost; cytokine; energy balance; epidemiologic data; genetic variant; health disparity; human FRAP1 protein; insulin-related factor; interest; lifestyle factors; malignant breast neoplasm; mortality; neoplasm registry; population based; programs; ribosomal protein S6 kinase, 70kD, polypeptide 2; social; tumor; tumor registry

The incidence rates of breast cancer vary more than two-fold between Hispanic and non-Hispanic white (NHW) women; Hispanic women have worse survival after diagnosis than NHW women. We propose to evaluate these health disparities in breast cancer development and surival along the continuation of American Indian to NHW women utilizing existing resources from the 4 Corner's States, California, and Mexico City. Existing resources utilized will be behorial and social lifestyle exposure data along with DNA obtained at the time of interview. Survival data has been ongoing and will continue to be monitored via local SEER and CDC tumor registries. Genetic and lifestyle data are available from approximately 8039 Hispanic and NHW cases of breast cancer and population-based controls. By pooling resources from three studies, we will efficiently examine a biological pathway that we believe is important to breast cancer development and survival and that influences differences in breast cancer rates among Hispanic and NHW women. Evaluation of genetic factors will focus on a pathway that appears to work in conjunction with insulin-, estrogen-, and inflammation-related pathways and represents a point of convergence. This pathway, which we call the Convergence of Hormones, Inflammation, and Energy Functioning (CHIEF) Signaling Pathway has not been studied comprehensively in either Hispanic or non-Hispanic white women and will include enes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, & S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform. Breast cancer associations will be tested between genetic polymorphisms and haplotypes of these genes in Hispanic and NHW women and by proportion of American Indian ancestry. Interaction of signaling pathway genes with each other and with NSAIDs, aspirin, BMI, estrogen, and physical activity will be examined. These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women.

西班牙裔和非西班牙裔之间的乳腺癌发病率差异超过两倍。 非西班牙裔白色（NHW）女性;西班牙裔女性在诊断后生存率更差 比NHW的女人多我们建议评估乳腺癌中的这些健康差异 沿着美洲印第安人对新南威尔士妇女的延续， 利用四角州、加州和墨西哥城的现有资源。 利用的现有资源将是行为和社会生活方式暴露数据，以及沿着 采访时获得的DNA。生存数据一直在进行中，并将继续 通过当地SEER和CDC肿瘤登记处进行监测。基因和生活方式数据 可从大约8039例西班牙裔和NHW乳腺癌病例中获得， 人口控制。通过集中三项研究的资源，我们将有效地 研究我们认为对乳腺癌发展很重要的生物学途径 和生存率，这影响了西班牙裔和 NHW女性遗传因素的评估将集中在一个途径，似乎工作 与胰岛素、雌激素和炎症相关的途径结合， 代表了一个汇聚点这条路，我们称之为 激素、炎症和能量功能（CHIEF）信号通路 尚未在西班牙裔或非西班牙裔白色女性中进行全面研究， 将包括待研究的烯，包括SOC 1、SOC 2、AKT、FRAP 1（别名mTOR）、P13 K， STK11、AMP、PTEN、VEGF、& S6K1、S6K2、CRP、NF κ B、IKB、IL10、IL8、IL6、TNF α 使用Illumina平台。乳腺癌的关联性将在遗传学之间进行测试。 这些基因在西班牙裔和NHW妇女中的多态性和单倍型， 美洲印第安人血统的比例。信号通路基因与 彼此和与非甾体抗炎药，阿司匹林，BMI，雌激素和体力活动将 考察这些遗传因素将与生存率进行评估，以确定其 西班牙裔和NHW女性的生存差异。

项目成果

Associations between ALDH1A1 polymorphisms, alcohol consumption, and mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer: the Breast Cancer Health Disparities Study.

诊断患有乳腺癌的西班牙裔和非西班牙裔白人女性中 ALDH1A1 多态性、饮酒量和死亡率之间的关联：乳腺癌健康差异研究。

• DOI: 10.1007/s10549-017-4600-2
• 发表时间: 2018
• 期刊: Breast cancer research and treatment
• 影响因子: 3.8
• 作者: Xia,Zhiyu;Baumgartner,KathyB;Baumgartner,RichardN;Boone,StephanieD;Hines,LisaM;John,EstherM;Wolff,Roger;Slattery,MarthaL;Connor,AvonneE
• 通讯作者: Connor,AvonneE