Tumor Ablation using Radiofrequency

使用射频进行肿瘤消融

基本信息

  • 批准号:
    6633828
  • 负责人:
  • 金额:
    $ 31.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-03-01 至 2005-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: (Adapted from the investigator's abstract) The long range goal of this research project is to develop and optimize image-guided radiofrequency (RF) tumor ablation in patients. The development of minimally-invasive thermal tumor ablation therapies is a major interest of interventional radiologists and is a designated specific interest of the Diagnostic Imaging Program of the NCI, particularly for focal liver lesions, given the morbidity of surgical resection and the large number of inoperable patients. While RF has been successful in ablating small tumors, the extent of tumor destruction obtained has been limited by tissue physiology. This proposal assesses the unique potential of adjuvant, pharmacologic modulation to alter the biologic environment during RF ablation to overcome this barrier. Their preliminary studies in models demonstrate that direct injection or systemic administration of agents that reduce blood flow and/or alter tissue conductivity during RF substantially increases tissue heating and coagulation compared to RF alone. However, further study is required prior to adapting these strategies for clinical practice, as pharmacologic manipulations may exert variable effects on ablation in tumors. Thus, this proposal will have a direct and immediate impact on the future research directions and the clinical implementation of RF tumor ablation. The three hypotheses to be studied include: 1) that RF heating and resultant coagulation correlate inversely with blood flow in tumors; 2) that RF heating and coagulation correlate with tissue conductivity to maximum values and then decrease; and 3) that combined techniques to decrease blood flow and alter tissue conductivity during RF have synergistic effects on tissue heating and coagulation compared to either technique alone. This will be accomplished by: a) characterizing the effects of blood flow on RF ablation efficacy in rabbit VX2 carcinoma and rat R3230 mammary adenocarcinoma tumor models using vasoactive pharmaceuticals; b) characterizing the effects of altering tissue conductivity with pre-treatment saline injection on RF ablation efficacy in R3230 and normal swine liver models; and c) optimizing the combined effects of altered blood flow and tissue conductivity on RF ablation efficacy with directly injected ethanol or acetic acid diluted in saline in the R3230 model; and/or d) combined systemic and injection adjuvant therapies in all three models. RF tissue heating and coagulation will be compared to determine the best method for increasing RF ablation efficacy in each tumor and tissue model.
描述:(改编自研究者摘要) 本研究项目是开发和优化图像引导射频 (RF)患者的肿瘤切除术。微创热疗技术的发展 肿瘤消融治疗是介入放射科医师的主要兴趣, 是NCI诊断成像计划的指定特定兴趣, 特别是对于局灶性肝脏病变,考虑到手术切除的发病率 以及大量无法手术的病人虽然RF在 切除小肿瘤,获得的肿瘤破坏程度已被 受到组织生理学的限制。该提案评估了以下方面的独特潜力: 辅助、药理学调节以改变RF期间的生物环境 消融以克服这一障碍。他们对模型的初步研究 证明直接注射或全身给予药物, 在RF期间显著减少血流和/或改变组织传导性 与单独RF相比,增加了组织加热和凝固。但进一步 在将这些策略应用于临床实践之前,需要进行研究, 药理学操作可以对肿瘤中的消融产生不同的影响。 因此,这项建议对未来有直接和即时的影响 射频肿瘤消融的研究方向和临床实施。 要研究的三个假设包括:1)射频加热和合成 凝血与肿瘤中的血流呈负相关; 2)RF加热 和凝血与组织电导率相关到最大值, 减少;和3)结合技术,以减少血流量和改变 RF期间的组织传导性对组织加热具有协同效应, 与单独使用任何一种技术相比,这将通过以下方式实现: a)表征兔中血流对RF消融功效的影响 VX 2癌和大鼠R3230乳腺癌肿瘤模型, 血管活性药物; B)表征改变组织的作用, 预处理盐水注射对射频消融有效性的影响 R3230和正常猪肝模型;以及c)优化以下的组合效果: 血流和组织电导率改变对射频消融有效性的影响, 在R3230模型中直接注射乙醇或稀释在盐水中的乙酸; 和/或d)在所有三种治疗中联合全身和注射辅助疗法 模型将比较射频组织加热和凝固,以确定 在每种肿瘤和组织模型中提高射频消融疗效的最佳方法。

项目成果

期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Radiofrequency tumor ablation: insight into improved efficacy using computer modeling.
射频肿瘤消融:利用计算机建模洞察提高疗效。
  • DOI:
    10.2214/ajr.184.4.01841347
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Liu,Zhengjun;Lobo,SMelvyn;Humphries,Stanley;Horkan,Clare;Solazzo,StephanieA;Hines-Peralta,AndrewU;Lenkinski,RobertE;Goldberg,SNahum
  • 通讯作者:
    Goldberg,SNahum
RF tumour ablation: computer simulation and mathematical modelling of the effects of electrical and thermal conductivity.
射频肿瘤消融:电导率和导热率影响的计算机模拟和数学建模。
Image-guided percutaneous chemical and radiofrequency tumor ablation in an animal model.
动物模型中图像引导的经皮化学和射频肿瘤消融。
  • DOI:
    10.1097/01.rvi.0000083254.29749.e1
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ahmed,Muneeb;Weinstein,Joseph;Liu,Zhengjun;Afzal,KarimS;Horkan,Clare;Kruskal,JonathanB;Goldberg,SNahum
  • 通讯作者:
    Goldberg,SNahum
Radiofrequency thermal ablation sharply increases intratumoral liposomal doxorubicin accumulation and tumor coagulation.
  • DOI:
  • 发表时间:
    2003-10
  • 期刊:
  • 影响因子:
    11.2
  • 作者:
    Muneeb Ahmed;Wayne E. Monsky;G. Girnun;A. Lukyanov;G. D’ippolito;J. Kruskal;K. Stuart;V. Torchilin;S. Goldberg
  • 通讯作者:
    Muneeb Ahmed;Wayne E. Monsky;G. Girnun;A. Lukyanov;G. D’ippolito;J. Kruskal;K. Stuart;V. Torchilin;S. Goldberg
Computer modeling of factors that affect the minimum safety distance required for radiofrequency ablation near adjacent nontarget structures.
对影响邻近非目标结构附近射频消融所需的最小安全距离的因素进行计算机建模。
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S. NAHUM GOLDBERG其他文献

S. NAHUM GOLDBERG的其他文献

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{{ truncateString('S. NAHUM GOLDBERG', 18)}}的其他基金

Combined Cancer Therapy with RF Ablation and Drug-Loaded Nanopreparations
射频消融和载药纳米制剂的联合癌症治疗
  • 批准号:
    7984270
  • 财政年份:
    2010
  • 资助金额:
    $ 31.59万
  • 项目类别:
Enhanced RF Tumor Ablation with Liposomal Chemotherapy
脂质体化疗增强射频肿瘤消融
  • 批准号:
    7108684
  • 财政年份:
    2004
  • 资助金额:
    $ 31.59万
  • 项目类别:
Enhanced RF Tumor Ablation with Liposomal Chemotherapy
脂质体化疗增强射频肿瘤消融
  • 批准号:
    7257007
  • 财政年份:
    2004
  • 资助金额:
    $ 31.59万
  • 项目类别:
Enhanced RF Tumor Ablation with Liposomal Chemotherapy
脂质体化疗增强射频肿瘤消融
  • 批准号:
    6929231
  • 财政年份:
    2004
  • 资助金额:
    $ 31.59万
  • 项目类别:
Enhanced RF Tumor Ablation with Liposomal Chemotherapy
脂质体化疗增强射频肿瘤消融
  • 批准号:
    7437265
  • 财政年份:
    2004
  • 资助金额:
    $ 31.59万
  • 项目类别:
Enhanced RF Tumor Ablation with Liposomal Chemotherapy
脂质体化疗增强射频肿瘤消融
  • 批准号:
    6821197
  • 财政年份:
    2004
  • 资助金额:
    $ 31.59万
  • 项目类别:
Tumor Ablation using Radiofrequency
使用射频进行肿瘤消融
  • 批准号:
    6325528
  • 财政年份:
    2001
  • 资助金额:
    $ 31.59万
  • 项目类别:
Tumor Ablation using Radiofrequency
使用射频进行肿瘤消融
  • 批准号:
    6514724
  • 财政年份:
    2001
  • 资助金额:
    $ 31.59万
  • 项目类别:
Tumor Ablation using Radiofrequency
使用射频进行肿瘤消融
  • 批准号:
    6495903
  • 财政年份:
    2001
  • 资助金额:
    $ 31.59万
  • 项目类别:
Combined Cancer Therapy with RF Ablation and Drug-Loaded Nanopreparations
射频消融和载药纳米制剂的联合癌症治疗
  • 批准号:
    8710071
  • 财政年份:
  • 资助金额:
    $ 31.59万
  • 项目类别:

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