The genetic adaptations of modern humans to their local environments

现代人类对其当地环境的遗传适应

• 批准号: 2241818
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2241818
• 关键词: genetic; adaptations; modern; humans; their

Modern humans lived in Africa for millions of years, colonising the rest of the world in the last 50,000-100,000 years. Each new environment differed in ecological factors as important as climate, diet or pathogens, and their colonisation was accompanied by strong pressure to adapt. The resulting genetic adaptations live today as genetic differences among populations, and contribute critically to the phenotypic diversity found in humans today. This project aims to combine modern and ancient genomes to quantify the influence of local adaptation in population differentiation, to identify the loci mediating these adaptations, and to determine their influence in phenotypic diversity.

现代人类在非洲生活了数百万年，在过去的5万到10万年里殖民了世界其他地区。每一个新的环境在气候、饮食或病原体等重要的生态因素上都不同，它们的殖民伴随着强大的适应压力。由此产生的遗传适应性今天作为种群之间的遗传差异而存在，并对今天人类的表型多样性做出了重要贡献。该项目旨在将联合收割机现代和古代基因组结合起来，以量化当地适应对种群分化的影响，确定介导这些适应的基因座，并确定它们对表型多样性的影响。