NEUROCOGNITIVE FUNCTION, HIV LOAD AND SURROGATE MARKERS

神经认知功能、HIV 载量和替代标志物

• 批准号: 6762089
• 负责人: LEON G EPSTEIN
• 金额: $ 52.11万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6762089
• 关键词: AIDS /HIV neuropathy; behavioral /social science research tag; biomarker; cognition disorders; human immunodeficiency virus 1; virus load

Quantitative assessment of plasma HIV load (RNA copy number) is a powerful predictor of systemic disease progression and response to anti-retroviral therapy. The prognostic value of HIV levels in plasma and CSF for neurologic decline have not been well studied. This may be particularly relevant in an era of potent combination antiretroviral therapy, where the potential exists for complete systemic suppression of HIV, with perhaps brain sequestration and persistent replication. HIV induced neural damage is mediated by products of activated macrophages/microglia. We previously established a cohort of 273 HIV infected subjects, with, or at risk for, neurocognitive abnormalities, utilizing the Dana Consortium, consisting of investigators from 3 institutions: The University of Rochester(UR), Columbia University(CU) and John Hopkins University(JHU). This is the largest, most ethnically, racially and gender diverse cohort assembled to date to study neurologic impairment. We propose: to recruit additional subjects to maintain a cohort of 200 subjects (N=460 over 5 years). Project 1 (CU) will perform cross=sectional and longitudinal analysis to determine if plasma HIV levels and markers of immune activation are independently associated with HIV minor cognitive/motor disorder (HIV- MCMD) or HIV Dementia (HIV-D). Project 2 (JHU) will focus on the prognostic significance of CSF HIV levels for neurologic decline, and examine the relationship between HIV levels and markers of immune activation in plasma, CSF and brain. Project 3 (CU) will determine the relationship between HIV levels, immune activation and severity of functional impairment (neurologic and psychiatric). Core A (UR) will provide administrative functions, data management and biostatistics support. Assays of HIV load (NASBA) and for markers of immune activation for all three projects will be centralized at Core B (JHU). This PPG builds on the existing infrastructure of the Dana Consortium, a consortium with a demonstrated ability to achieve research objectives. The investigators provide complementary expertise for site specific projects. This diverse cohort of subjects with advanced HIV infection provides a unique opportunity to investigate the relationship between virus load, immune activation and the progression of neurologic dysfunction during HIV infection.

定量评估血浆HIV载量（RNA拷贝数）是一项强有力的技术

项目成果

Diffusion alterations in corpus callosum of patients with HIV.

• 发表时间: 2006-03
• 期刊: AJNR. American journal of neuroradiology
• 作者: Ying Wu;P. Storey;B. Cohen;L. Epstein;R. Edelman;A. Ragin

The International HIV Dementia Scale: a new rapid screening test for HIV dementia.

国际艾滋病毒痴呆量表：一种新的艾滋病毒痴呆快速筛查测试。

• 发表时间: 2005
• 期刊: AIDS (London, England)
• 作者: Sacktor,NedC;Wong,Matthew;Nakasujja,Noeline;Skolasky,RichardL;Selnes,OlaA;Musisi,Seggane;Robertson,Kevin;McArthur,JustinC;Ronald,Allan;Katabira,Elly
• 通讯作者: Katabira,Elly

Bone marrow diffusion measures correlate with dementia severity in HIV patients.

骨髓扩散测量与艾滋病毒患者的痴呆严重程度相关。

• 发表时间: 2006
• 期刊: AJNR. American journal of neuroradiology
• 作者: Ragin,AB;Wu,Y;Storey,P;Cohen,BA;Edelman,RR;Epstein,LG;Gartner,S
• 通讯作者: Gartner,S

Whole brain diffusion tensor imaging in HIV-associated cognitive impairment.

• 发表时间: 2004-02
• 期刊: AJNR. American journal of neuroradiology
• 作者: A. Ragin;P. Storey;B. Cohen;L. Epstein;R. Edelman