Improving neurologic outcome measurement for interventional research in Ibadan

描述（由申请人提供）：迫切需要旨在建立研究能力的医学教育计划，以减轻尼日利亚神经系统疾病的负担。严重的公共卫生问题在生命的各个阶段-子宫内、婴儿期、儿童期、成年期和衰老期-都威胁着大脑和认知功能。本申请是响应RFA-TW-11-004（医学教育合作伙伴关系倡议关联奖（MEPI）- R25）提交的，概述了一项创新的研究教育计划，涉及伊巴丹大学/伊巴丹大学学院医院（UI/UCH）的神经学家和神经放射学家与芝加哥西北大学的临床医生和科学家组成的多学科团队之间的合作。该计划结合了大脑研究方法的正规教育，成人和儿科神经学的强化临床研究培训机会以及远程学习。此外，UI/UCH临床使用的尚未用于研究的主要成像设备将扩大用于大脑成像研究。由于成像技术可以用于研究几乎任何受伤或完好的大脑在任何阶段的生命，这将是一个重大的进步，在建设神经学研究能力。该计划将为我们主要针对成人（中风）和儿童的公共卫生问题带来益处 （癫痫）神经学。然而，重要的是要认识到，这些同样的工具将在建设研究能力方面产生广泛的回报，其益处扩展到许多神经和精神公共卫生威胁，包括脑血管疾病、神经退行性疾病、脑创伤、中枢神经系统感染、神经发育障碍、吸毒成瘾和精神疾病。在该计划中获得的技能可用于设计可行的调查，以确定有效的预防策略，改善诊断， 评估神经学结果，并评估旨在保护神经、保护认知功能和生活质量的干预措施。 这一培训方案将大大加强UI/UCH现有的医学教育系统，UI/UCH是斐济的旗舰公立大学和最古老的高等教育机构。参与的医生将能够通过指导同事，当地合作者和未来几代学生，居民和研究员进一步建立神经学研究能力。该项目将对尼日利亚的神经学研究能力产生持续和不断扩大的影响。

DESCRIPTION (provided by applicant): Medical education programs aimed at building research capacity are urgently needed to relieve the burden of neurological disease in Nigeria. Serious public health issues threaten the brain and cognitive function at all stages of the lifespan -- in utero, infancy, childhood, adulthood and with aging. This application, submitted in response to RFA-TW-11-004 (The Medical Education Partnership Initiative Linked Awards (MEPI) - R25), outlines an innovative research education plan involving a partnership between neurologists and neuroradiologists from the University of Ibadan/University College Hospital (UI/UCH) in Ibadan and a multidisciplinary team of clinicians and scientists from Northwestern University in Chicago. The plan combines formal education in methodology for studies of the brain, intensive clinical research training opportunities in adult and pediatric neurology and remote learning. In addition, major imaging equipment in clinical use at UI/UCH that has not yet been exploited for research will be scaled up for imaging studies of the brain. Because imaging technology can be used to study nearly any injured or intact brain at any stage of the lifespan, this will represent a significant advance in building neurological research capacity. This program will yield benefits for our primary targeted public health concerns in adult (stroke) and pediatric (epilepsy) neurology. It is important to appreciate, however, that these same tools will yield broad returns in building research capacity, with benefits that extend to many neurological and psychiatric public health threats including cerebrovascular disease, neurodegenerative disorders, brain trauma, central nervous system infections, neurodevelopmental disorders, drug addiction and psychiatric disorders. The skills acquired in this program can be used to design feasible investigations for identifying effective prevention strategies, improving diagnostics, for evaluation of neurological outcome and for evaluating interventions aimed at neuroprotection, preservation of cognitive function and quality of life. This training program will significantly strengthen the existing medical education system at the UI/UCH, which is the flagship public university and oldest institution of higher learning in Nigeri. Participating physicians will be able to build neurological research capabilities further by mentoring colleagues, local collaborators and future generations of students, residents and fellows. This program will yield a sustained and expanding impact on neurological research capabilities in Nigeria.