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Neurobiology of Spatial Learning in Food-Hoarding Birds

囤积食物的鸟类空间学习的神经生物学

基本信息

批准号：
6639059
负责人：
TIMOTHY J DEVOOGD
金额：
$ 11.89万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2005-03-31
项目状态：
已结题

项目摘要

DESCRIPTION: (Adapted from applicant's abstract): Learning and remembering spatial relations is an important human capacity. Many lines of evidence suggest that the hippocampus is essential for this form of learning, both in humans and in animals. However, much less is known of how spatial relations are encoded in the hippocampus or of how the hippocampus changes as learning of spatial relations occurs. This application will study the substrate for spatial learning using a novel animal model: seed storage in birds. Several species of birds hide large numbers of seeds and are able to retrieve them reliably weeks or months later. Several studies suggest that the hippocampus is necessary for the learning--it is larger in species that store than in related ones that do not, and birds that store are unable to retrieve if the hippocampus is lessoned. The P.I. and colleagues showed that the volume of the avian hippocampus increases in juveniles with the onset of storage and retrieval, and fluctuates seasonally in adults with use of seed storage and retrieval. This demonstrates that the structure of this complex neural network is modified in adulthood to allow for (or to encode) spatial learning. Furthermore, inactivating the hippocampus disrupts retrieval based on spatial cues. Experiments in the present proposal build on these findings. One series of experiments will measure changes in the structure and projections of hippocampal neurons from spring to fall, as the birds increase their storage and retrieval. Plastic changes in anatomy will be compared to observations in a species that does not store food. We will try to determine the cause for the fall changes in behavior and neuroanatomy. A second series of experiments will examine hippocampal functioning. Two experiments will impair neuronal activity and look for changes in spatial learning or recall. A third will use immediate early gene expression as a marker of the neuronal activity associated with recall of spatial memories. It is intended to determine whether retrieving recent and remote spatial memories activates the same neural substrate. This proposal assesses several major aspects of the neurobiology of avian spatial learning. It searches for structural features related to the behavioral capacity, for long term structural change in the system related to seasonal changes in the frequency of the behavior, and for short term changes related to use. Each of these issues is closely related to human spatial learning, its neural substrate and its capacity for change.

描述：（改编自申请人的摘要）：学习和记忆空间关系是人类的一种重要能力。许多证据表明海马体对于这种形式的学习至关重要，无论是在人类和动物。然而，人们对空间关系的了解却少之又少。编码在海马体中或海马体如何随着学习而变化空间关系发生。该应用程序将研究空间基底使用新颖的动物模型进行学习：鸟类的种子储存。几个品种鸟类隐藏大量种子并能够在数周内可靠地取回它们或几个月后。多项研究表明海马体对于学习能力——具有储存能力的物种比相关物种具有更大的学习能力不会，如果海马体不正常，鸟类就无法检索储存的信息。受过教训。 P.I.和同事表明，鸟类的体积随着存储和检索的开始，青少年的海马体增加，并且随着种子储存和检索的使用，成人的季节性波动。这证明了这个复杂神经网络的结构被修改为成年后允许（或编码）空间学习。此外，海马体失活会扰乱基于空间线索的检索。本提案中的实验建立在这些发现的基础上。一个系列的实验将测量结构和预测的变化从春天到秋天，海马神经元随着鸟类的储存而增加和检索。解剖学上的塑性变化将与观察到的结果进行比较不储存食物的物种。我们将尝试确定问题的原因秋季行为和神经解剖学的变化。第二系列实验将检查海马体功能。二实验将损害神经元活动并寻找空间变化学习或回忆。第三个将使用立即早期基因表达作为与空间记忆回忆相关的神经元活动的标记。它旨在确定是否检索最近和遥远的空间记忆激活相同的神经底物。该提案评估了鸟类神经生物学的几个主要方面空间学习。它搜索与行为相关的结构特征容量，用于与季节性相关的系统的长期结构变化行为频率的变化，以及与相关的短期变化使用。这些问题中的每一个都与人类的空间学习密切相关，其神经基质及其变化能力。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Non invasive in vivo anatomical studies of the oscine brain by high resolution MRI microscopy.

通过高分辨率 MRI 显微镜对脑部进行无创体内解剖研究。

DOI：
10.1016/s0165-0270(98)00013-2
发表时间：
1998
期刊：
Journal of neuroscience methods
影响因子：
3
作者：
VanderLinden,A;Verhoye,M;VanAuderkerke,J;Peeters,R;Eens,M;Newman,SW;Smulders,T;Balthazart,J;DeVoogd,TJ
通讯作者：
DeVoogd,TJ

Long-term memory for spatial locations in a food-storing bird (Poecile atricapilla) requires activation of NMDA receptors in the hippocampal formation during learning.