IL microemulsion extractions

IL微乳液提取

• 批准号: 2252748
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2252748
• 关键词: IL; microemulsion; extractions

BackgroundExtraction is a key purification tool in pharmaceutical manufacturing but is mostly done in batch operations. Problems occur with the formation of undesirable emulsions/phases and when extracting hydrophilic species. This research develops the chemistry and engineering of intensified/continuous extraction technology. Apart from traditional solvents, water-hydrophobic ionic liquid systems (IL) and ionic liquid based microemulsions will be used together with the intensified liquid extraction techniques to develop efficient continuous processes for Health. The work targets fast, flexible, low cost, reliable, and GMP-compliant pharmaceutical manufacturing technologies. EPSRC Research Areas addressed are: 1) Manufacturing Technologies, 2) Process systems - components and integration.The majority of Pharmaceutical manufacturing processes have been not only traditionally but also recently done exclusively in batch operation. Modern pharmaceutical manufacturing organizations would like extraction processes that can integrate with continuous up stream flow synthesis and downstream isolation procedures. In addition, continuous manufacturing offers a range of advantages for adaptation over batch including speed, scale minimization, flexibility and safety, making the transition long overdue. Continuous extraction can be achieved by the application of small scale, two-phase contactors. The reduction in size leads to intensification with advantages including increased mass transfer, minimisation of hazardous materials, improved control of hydrodynamics, reduced operating cost and capital cost due to the smaller size of equipment. The ThAMes multiphase group at UCL has developed continuous/ intensified solvent extraction systems including impinging jets and small channels that show high mass transfer and reduced solvent use and have been successfully employed in the past for metal extractions.In pharmaceutical processes the high cost associated with downstream processing aimed at the purification and recovery of target products is one of the major issues limiting the widespread use of many bio-base products. Separation processes and purification stages usually require numerous steps associated with high energy and chemicals consumption and represent a large percentage of the cost of the final product. Insufficient selectivity is a significant issue. In an one-step process this results in high product losses. The addition of a process auxiliary increases the number of impurities. The solvent should from a medicinal standpoint be as harmless as possible- a fact that dramatically limits the choice of agents. The use of ionic liquids can address this issue. Ionic liquids have high solvation capabilities and the potential to be green alternatives to conventional organic solvents. They have remarkable physicochemical properties such as low volatility, high thermal and chemical stability, low flammability. Aim-Objectives The aim of the project is to develop and exploit continuous intensified extractions of 'hydrophobic water' microemulsions based on ILs and to study their application in efficient pharmaceutical solvent extraction processes. The plan for the PhD research is shown below. BackgroundExtraction is a key purification tool in pharmaceutical manufacturing but is mostly done in batch operations. Problems occur with the formation of undesirable emulsions/phases and when extracting hydrophilic species. This research develops the chemistry and engineering of intensified/continuous extraction technology. Apart from traditional solvents, water-hydrophobic ionic liquid systems (IL) and ionic liquid based microemulsions will be used together with the intensified liquid extraction techniques to develop efficient continuous processes for Health. The work targets fast, flexible, low cost, reliable, and GMP-compliant pharmaceutical manufacturing technologies. EPSRC Research Areas addressed are: 1) Manufacturing Tech

背景萃取是制药生产中的关键纯化工具，但主要是在批处理操作中进行。问题出现在不期望的乳液/相的形成和提取亲水性物质时。本研究发展了强化/连续萃取技术的化学和工程。除了传统的溶剂外，疏水性离子液体系统（IL）和基于离子液体的微乳液将与强化液体萃取技术一起使用，以开发用于健康的高效连续工艺。这项工作的目标是快速，灵活，低成本，可靠，符合GMP的制药技术。EPSRC的研究领域包括：1）制造技术，2）过程系统-组件和集成。大多数制药生产过程不仅传统上而且最近也完全采用批量操作。现代制药企业希望提取工艺能够与连续上游流动合成和下游分离程序相结合。此外，连续生产提供了一系列优于批量生产的优势，包括速度、规模最小化、灵活性和安全性，使过渡期姗姗来迟。连续提取可以通过应用小规模两相接触器来实现。尺寸的减小导致强化，其优点包括增加传质、使有害材料最小化、改进流体动力学控制、由于设备尺寸较小而降低操作成本和资本成本。伦敦大学学院的Thames多相组已经开发了连续/在制药工艺中，与旨在纯化和回收目标产物的下游处理相关的高成本是限制许多方法广泛使用的主要问题之一，生物基产品。分离过程和纯化阶段通常需要与高能量和化学品消耗相关的许多步骤，并且占最终产品成本的很大比例。选择性不足是一个重要问题。在一步法中，这导致高的产品损失。添加工艺助剂会增加杂质的数量。从医学的角度来看，溶剂应该尽可能无害-这一事实极大地限制了试剂的选择。离子液体的使用可以解决这个问题。离子液体具有很高的溶剂化能力，有望成为传统有机溶剂的绿色替代品。它们具有显著的物理化学性质，如低挥发性、高热稳定性和化学稳定性、低可燃性。目的-目的本项目的目的是开发和利用基于离子液体的“疏水水”微乳液的连续强化萃取，并研究其在高效药物溶剂萃取过程中的应用。博士研究计划如下所示。背景萃取是制药生产中的关键纯化工具，但主要是在批处理操作中进行。问题出现在不期望的乳液/相的形成和提取亲水性物质时。本研究发展了强化/连续萃取技术的化学和工程。除了传统的溶剂外，疏水性离子液体系统（IL）和基于离子液体的微乳液将与强化液体萃取技术一起使用，以开发用于健康的高效连续工艺。这项工作的目标是快速，灵活，低成本，可靠，符合GMP的制药技术。EPSRC的研究领域包括：1）制造技术