Nerve-muscle grafts in amputees for prosthesis control

截肢者的神经肌肉移植物用于假肢控制

• 批准号: 6675344
• 负责人: Todd Kuiken
• 金额: $ 16.27万
• 依托单位: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6675344
• 关键词: adult human (21+); amputation; arm; artificial limbs; assistive device /technology; bioengineering /biomedical engineering; biomedical equipment development; clinical research; clinical trials; electromyography; human subject; human therapy evaluation; innervation; medical rehabilitation related tag; muscle; nerve; occupational therapy; patient oriented research; rehabilitation

DESCRIPTION (provided by applicant): Currently transhumeral amputees can only operate a single degree-of-freedom at a time with myoelectric prostheses. This is very inadequate since multiple functions need to be controlled. We believe that the residual brachial plexus nerves in a transhumeral amputee can be grafted onto separate regions of the biceps, triceps and brachialis muscles and that these nerve-muscle grafts could provide additional myoelectric control signals that are physiologically related to the functions they would be controlling in the prosthesis. This would allow simultaneous control of multiple degrees-of-freedom with a more natural feel. The technique has great potential for improving the control of transhumeral myoelectric prostheses. A series of experiments have been performed that indicate the concept is feasible with a high probability of success. Since the muscles will be 'hyper-reinnervated' by the donor nerve, good muscle recovery is expected. Extensive EMG modeling studies indicate that surface EMG signals from the different nerve-muscle grafts will be able to provide discreet and independent control signals allowing simultaneous operation of a terminal device, elbow and wrist rotator. We propose a small, carefully orchestrated clinical trial of the nerve-muscle graft technique in recent transhumeral amputees. Baseline testing will be done with a conventional myoelectric prosthesis to measure operational performance. With IRB approval, surgery will be performed to denervate the medial head of the biceps and brachialis muscles, then graft the median and distal radial nerves on to these muscles. Once the muscles are reinnervated, the patient will be fit with an appropriately modified myoelectric prosthesis and trained in its use. The patient will then be able to use the nerve grafts to control a myoelectric hand and the lateral head of the biceps and the triceps to control the powered elbow. Performance testing will be repeated with the experimental myoelectric system for comparison to conventional measures.

描述（由申请人提供）：目前经肱骨截肢者使用肌电义肢一次只能操作一个自由度。这是非常不足的，因为需要控制多个功能。我们认为，经肱骨截肢者体内残留的臂丛神经可以移植到肱二头肌、肱三头肌和肱肌的不同区域，这些神经-肌肉移植物可以提供额外的肌电控制信号，这些信号在生理上与它们在假肢中控制的功能相关。这将使玩家能够同时控制多个自由度，并获得更自然的感觉。该技术在改善经肱骨肌电假体的控制方面具有很大的潜力。