Developing clinical decision support tools to characterize neurodegenerative disorders using biomedical speech signal processing and statistical machi

点击翻译按钮获取中文摘要

BackgroundThe population is aging globally, presenting important societal challenges and straining national health systems to meet increasing demand for healthcare delivery. The rise of new technologies, including smartphones and smartwatches, provides a unique opportunity to revolutionize contemporary healthcare delivery through the collection of additional signal modalities, without requiring frequent physical visits of people into clinics. Speech is a signal modality which is easy to collect, requires minimal equipment, and has been shown to convey clinically important information on neurodegenerative conditions such as Parkinson's Disease (PD). We have previously shown that speech can be used to differentiate healthy controls from people with Parkinson's disease and replicate the standard symptom severity metric Universal Parkinson's Disease Rating Scale (UPDRS) [1]. We have also demonstrated the use of speech to assess remote PD rehabilitation [2]. Furthermore, we have reported initial explorations towards understanding phonation biomechanics of speech signal degradation, thus gaining a more mechanistic insight into PD symptom severity progression [3]. More recently, we have shown that speech could be used as an early biomarker of PD associated with genetic information [4]. Overall, the field of biomedical speech signal processing is rapidly expanding and has generated considerable research interest over the past few years. Aims The framework of this project is to further investigate the potential of speech signals, with the goal of studying and monitoring the manifestation and progression of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. The student will apply algorithms we have previously developed and extend approaches towards improving the characterization of neurodegenerative diseases. Previous studies have only contrasted a group with a neurodegenerative disorder and healthy controls; they have not developed tools towards differential diagnosis (i.e. tackling the problem of differentiating diseases and considering potential co-morbidities). This project will extend previous work to investigate imprints of different neurodegenerative disorders on speech signals towards improving understanding of disease progression and treatment planning. We have rich data resources from clinical collaborators based in the US, Australia, and Spain, which is readily available, and which has been previously used in publications in our group. Moreover, our clinical colleagues in Madrid, Spain (led by co-supervisor Victor Nieto-Lluis) have already started data collection across a range of neurodegenerative disorders, including speech signals and disease-specific clinical markers. The recruited student will be primarily working on developing novel time-series, signal processing, and pattern recognition algorithms, and extending statistical machine learning algorithms to develop a robust user-friendly clinical decision support tool to characterize neurodegenerative disorders.Training outcomes Practical understanding of the problems at the interface of clinical practice and data analytics, including the language barrier with niche terminology on both ends Developing expertise in time-series analysis, signal processing, and statistical machine learning to tackle large-scale challenging problems Programming skills: transforming algorithmic concepts to software tools, and developing interfaces which can be used by experts