MULTICHANNEL SILICON ELECTRODES IN NEURAL PROSTHESES: VISUAL, AUDITORY & MOTOR

神经假体中的多通道硅电极：视觉、听觉

• 批准号: 6660153
• 负责人: DAVID JAMES ANDERSON
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6660153
• 关键词: Mammalia; animal tissue; bioengineering /biomedical engineering; biomaterials; biomedical equipment development; biomedical resource; medical rehabilitation related tag; nervous system; prosthesis; technology /technique

Observation of multichannel activity or stimulation with probes in the periphery is particularly challenging. First, simple penetration of a nerve track is much more difficult than brain tissue. We have solved this problem by fabricating probes with very sharp tips formed using shallow boron diffusion. These probes have been shown to penetrate much more readily than those with standard deep diffused tips. "Sieve" electrodes can also be used when to record from regenerated nerve fibers (Highstein and Bradley). This type of probe has holes through which the fibers can regenerate, and recording sites which surround the holes. The second challenge involves motion with respect to surrounding fixation points is larger then in the cortex or brainstem. The device must somehow be fixed within the nerve track and a cable or transmission system which allows large motions relative to the interconnect area must be provided. We have included barbs and suture loops/holes on several of the custom designs to enhance positional stability. Cables on these designs have been slotted to increase flexibility. Third, in many peripheral situations signals must be transmitted a relatively long distance to reach (or be sent from) the external world. We continue to work with PI Medical in Portland, Oregon to develop a combined system for Dr. Highstein (see collaborative project on Post-processing and Packaging).

用探针观察多通道活动或刺激， 周边地区尤其具有挑战性。 第一，简单渗透 比脑组织要困难得多 我们有 通过制造具有非常尖锐的尖端的探针来解决这个问题 使用浅硼扩散。 这些探针已经被证明 比那些标准的深扩散的更容易穿透 提示. “筛”电极也可以用于记录从 再生神经纤维（Highstein和布拉德利）。 这种探头 有孔，通过这些孔，纤维可以再生， 其围绕孔。 第二个挑战涉及运动， 相对于周围固定点， 脑干 这个装置必须以某种方式固定在神经通道内 以及允许相对于第一和第二运动的大的运动的线缆或传动系统 必须提供到互连区域的连接。 我们已经包括倒钩和 几种定制设计上的缝合环/孔， 位置稳定性 这些设计中的电缆已开槽， 增加灵活性。 第三，在许多外围情况下，信号 必须传输相对较长的距离才能到达（或被发送 从）外部世界。 我们继续与PI Medical合作， 俄勒冈州的波特兰，为海斯坦博士开发一个组合系统（见 后处理和包装合作项目）。