MULTICHANNEL SILICON ELECTRODES IN NEURAL PROSTHESES: VISUAL, AUDITORY & MOTOR

用探头观察心脏多通道活动或刺激 外围国家尤其具有挑战性。第一，简单渗透 神经轨迹的研究比脑组织要难得多。我们有 通过制造尖端非常锋利的探头解决了这个问题 采用浅层硼扩散。这些探测器已经被证明是 比标准的深扩散更容易穿透 小费。“筛子”电极也可以在记录时使用 再生神经纤维(Highstein和Bradley)。这种类型的探头 有孔，纤维可以通过这些孔再生，以及记录地点 围绕着这些洞。第二个挑战涉及 相对于周围的凝视点来说，大脑皮质或 脑干。装置必须以某种方式固定在神经轨迹内 以及电缆或传输系统，其允许相对大的运动 必须提供到互连区的连接。我们已经包括了倒钩和 缝合几个定制设计上的环/孔以增强 位置稳定。这些设计上的电缆已开槽以 提高灵活性。第三，在许多外围情况下，信号 必须传输相对较长的距离才能到达(或被发送 来自)外部世界。我们继续与Pi Medical在 俄勒冈州波特兰将为海斯坦博士开发一种联合系统(见 后处理和包装合作项目)。

Observation of multichannel activity or stimulation with probes in the periphery is particularly challenging. First, simple penetration of a nerve track is much more difficult than brain tissue. We have solved this problem by fabricating probes with very sharp tips formed using shallow boron diffusion. These probes have been shown to penetrate much more readily than those with standard deep diffused tips. "Sieve" electrodes can also be used when to record from regenerated nerve fibers (Highstein and Bradley). This type of probe has holes through which the fibers can regenerate, and recording sites which surround the holes. The second challenge involves motion with respect to surrounding fixation points is larger then in the cortex or brainstem. The device must somehow be fixed within the nerve track and a cable or transmission system which allows large motions relative to the interconnect area must be provided. We have included barbs and suture loops/holes on several of the custom designs to enhance positional stability. Cables on these designs have been slotted to increase flexibility. Third, in many peripheral situations signals must be transmitted a relatively long distance to reach (or be sent from) the external world. We continue to work with PI Medical in Portland, Oregon to develop a combined system for Dr. Highstein (see collaborative project on Post-processing and Packaging).