MULTICHANNEL SILICON ELECTRODES IN NEURAL PROSTHESES: VISUAL, AUDITORY & MOTOR

神经假体中的多通道硅电极：视觉、听觉

• 批准号: 6505242
• 负责人: DAVID JAMES ANDERSON
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6505242
• 关键词: Mammalia; animal tissue; bioengineering /biomedical engineering; biomaterials; biomedical equipment development; biomedical resource; medical rehabilitation related tag; nervous system; prosthesis; technology /technique

Observation of multichannel activity or stimulation with probes in the periphery is particularly challenging. First, simple penetration of a nerve track is much more difficult than brain tissue. We have solved this problem by fabricating probes with very sharp tips formed using shallow boron diffusion. These probes have been shown to penetrate much more readily than those with standard deep diffused tips. "Sieve" electrodes can also be used when to record from regenerated nerve fibers (Highstein and Bradley). This type of probe has holes through which the fibers can regenerate, and recording sites which surround the holes. The second challenge involves motion with respect to surrounding fixation points is larger then in the cortex or brainstem. The device must somehow be fixed within the nerve track and a cable or transmission system which allows large motions relative to the interconnect area must be provided. We have included barbs and suture loops/holes on several of the custom designs to enhance positional stability. Cables on these designs have been slotted to increase flexibility. Third, in many peripheral situations signals must be transmitted a relatively long distance to reach (or be sent from) the external world. We continue to work with PI Medical in Portland, Oregon to develop a combined system for Dr. Highstein (see collaborative project on Post-processing and Packaging).

用探针观察多通道活动或刺激