Diet and Prostate Cancer Risk

饮食与前列腺癌风险

• 批准号: 6576095
• 负责人: JACKILEN SHANNON
• 金额: $ 15.91万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-25 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6576095
• 关键词: biopsy; blood chemistry; cancer prevention; cancer risk; clinical research; computer data analysis; data collection methodology /evaluation; dietary lipid; gas chromatography; gene environment interaction; human subject; immunocytochemistry; nutrition related neoplasm /cancer; nutrition related tag; omega 3 fatty acid; prostaglandin E; prostaglandin endoperoxide synthase; prostate neoplasms; questionnaires; unsaturated fatty acids

DESCRIPTION (provided by applicant): The foundation of my career plan lies within a desire to build upon my solid background in nutritional epidemiology and cancer prevention with training and research experience in genetic epidemiology. My overall career goal is to establish a strong research program in diet and gene interactions in the prevention and progression of cancer, specifically prostate cancer and breast cancer. More immediately my goal is to develop a research agenda to assess the association between dietary fat and prostate cancer risk. This agenda will include a series of projects beginning with a case-control study to evaluate the association between dietary polyunsaturated fatty acid intake and prostate cancer risk and to determine whether polyunsaturated fatty acids function through the cyclooxygenase pathway to alter prostate cancer risk. This research project, in addition to being scientifically stimulating also provides me with an opportunity to work closely with geneticists, genetic epidemiologists, and oncologists to develop my knowledge and practical skills in genetic epidemiology. The Oregon Health Sciences University (OHSU) provides an ideal environment for pursuing this research agenda. OHSU together with the Oregon Cancer Institute have a clear interest in supporting cancer prevention and control research. My particular area of interest ties in well with an established program in Molecular Biology and Genetics as well as with the research interests of other established investigators at OHSU. The Public Health Preventive Medicine program provides senior collaborators in epidemiology and biostatistics as well as staff support. OHSU is physically located adjacent to the Portland VA Medical Center, providing OHSU researchers the unique opportunity to collaborate with VA researchers, and access to a large and well-described population of individuals.

本人的职业规划基于本人在营养流行病学和癌症预防方面的扎实背景，以及在遗传流行病学方面的培训和研究经验。我的总体职业目标是建立一个强有力的研究项目，研究饮食和基因相互作用在癌症预防和进展中的作用，特别是前列腺癌和乳腺癌。更直接的目标是制定一项研究议程，评估膳食脂肪与前列腺癌风险之间的关系。该议程将包括一系列项目，首先是一项病例对照研究，以评估饮食中多不饱和脂肪酸摄入量与前列腺癌风险之间的关系，并确定多不饱和脂肪酸是否通过环加氧酶途径改变前列腺癌风险。这个研究项目，除了科学上的刺激之外，还为我提供了一个与遗传学家、遗传流行病学家和肿瘤学家密切合作的机会，以发展我在遗传流行病学方面的知识和实践技能。俄勒冈健康科学大学（OHSU）为追求这一研究议程提供了理想的环境。OHSU与俄勒冈癌症研究所在支持癌症预防和控制研究方面有着明确的兴趣。我特别感兴趣的领域与分子生物学和遗传学的既定项目以及OHSU其他既定研究人员的研究兴趣密切相关。公共卫生预防医学计划提供流行病学和生物统计学方面的高级合作者以及工作人员支持。OHSU位于波特兰VA医疗中心附近，为OHSU的研究人员提供了与VA研究人员合作的独特机会，并获得了大量且描述良好的个体。