Diet and Prostate Cancer Risk

描述（由申请人提供）：我的职业计划的基础在于希望建立在我的营养流行病学和癌症预防的坚实背景与遗传流行病学的培训和研究经验。 我的总体职业目标是建立一个强大的研究计划，在饮食和基因相互作用的预防和癌症的进展，特别是前列腺癌和乳腺癌。 更直接的目标是制定一个研究议程，以评估膳食脂肪和前列腺癌风险之间的关联。 该议程将包括一系列项目，首先是病例对照研究，以评估膳食多不饱和脂肪酸摄入量与前列腺癌风险之间的关联，并确定多不饱和脂肪酸是否通过环氧合酶途径发挥作用来改变前列腺癌风险。 这个研究项目，除了在科学上刺激，也为我提供了一个机会，与遗传学家，遗传流行病学家和肿瘤学家密切合作，发展我在遗传流行病学的知识和实践技能。 俄勒冈州健康科学大学（OHSU）为追求这一研究议程提供了理想的环境。OHSU与俄勒冈州癌症研究所一起对支持癌症预防和控制研究有着明确的兴趣。 我感兴趣的领域与分子生物学和遗传学的既定计划以及OHSU其他既定研究人员的研究兴趣密切相关。 公共卫生预防医学计划提供流行病学和生物统计学方面的高级合作者以及工作人员支持。 OHSU的物理位置毗邻波特兰VA医疗中心，为OHSU研究人员提供了与VA研究人员合作的独特机会，并获得了大量和良好描述的个人群体。

DESCRIPTION (provided by applicant): The foundation of my career plan lies within a desire to build upon my solid background in nutritional epidemiology and cancer prevention with training and research experience in genetic epidemiology. My overall career goal is to establish a strong research program in diet and gene interactions in the prevention and progression of cancer, specifically prostate cancer and breast cancer. More immediately my goal is to develop a research agenda to assess the association between dietary fat and prostate cancer risk. This agenda will include a series of projects beginning with a case-control study to evaluate the association between dietary polyunsaturated fatty acid intake and prostate cancer risk and to determine whether polyunsaturated fatty acids function through the cyclooxygenase pathway to alter prostate cancer risk. This research project, in addition to being scientifically stimulating also provides me with an opportunity to work closely with geneticists, genetic epidemiologists, and oncologists to develop my knowledge and practical skills in genetic epidemiology. The Oregon Health Sciences University (OHSU) provides an ideal environment for pursuing this research agenda. OHSU together with the Oregon Cancer Institute have a clear interest in supporting cancer prevention and control research. My particular area of interest ties in well with an established program in Molecular Biology and Genetics as well as with the research interests of other established investigators at OHSU. The Public Health Preventive Medicine program provides senior collaborators in epidemiology and biostatistics as well as staff support. OHSU is physically located adjacent to the Portland VA Medical Center, providing OHSU researchers the unique opportunity to collaborate with VA researchers, and access to a large and well-described population of individuals.