MR assessment of brain function altered by lead exposure

铅暴露改变脑功能的 MR 评估

• 批准号: 6657533
• 负责人: KIM M CECIL
• 金额: $ 17.91万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657533
• 关键词: attention; behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; clinical research; developmental neurobiology; environmental exposure; environmental toxicology; functional magnetic resonance imaging; human subject; lead poisoning; magnetic resonance imaging; memory; neurochemistry; neurophysiology; neuropsychological tests; neurotoxins; social behavior disorders; young adult human (21-34)

DESCRIPTION (provided by applicant) Exposure to lead during pregnancy, infancy, and childhood increases the individual likelihood of impaired school performance, increased impulsiveness, aggression, and delinquent behavior. Disorders that result from exposure to environmental neurotoxicants are a complex web of interactions between genetic, neurochemical, biochemical, environmental and social factors that influence children during critical periods of development. To date, research in the area of human developmental neurotoxicology focuses primarily on global measures of sensory-motor development and cognition. However, human studies elucidating the biological basis for developmental and behavioral disorders due to environmental toxicant exposure are lacking. Although gross brain structure appears normal, underlying problems must exist at a neural level. This project seeks to correlate childhood environmental lead exposure with changes in brain structure, neurochemistry and function assessed with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Cortical and subcortical brain volumes will be determined with high resolution MRI. Neuronal and glial cell markers (N-acetyl aspartate, creatine, cholines and myo-inositol) will be measured using proton MRS. These structural and chemical measures will also be correlated with behavioral measures from the young adult participants of the Cincinnati Lead Study (CLS). These participants represent a unique and ideal study cohort of approximately 240 subjects with detailed histories of exposure and behavioral outcomes in lead exposed children monitored for approximately 20 years. As this cohort enters young adulthood, associations between childhood lead exposure and antisocial behaviors are emerging. While MRI and MRS provide structural and metabolic measures relevant to lead exposure, the significance to behavioral measures is limited. A pilot study (n=40) examining language, working memory and attention in combination with functional magnetic resonance imaging (fMRI) will also be performed to better investigate the correlation of functional and behavioral deficits.

描述（由申请人提供） 怀孕期间，婴儿期和童年的铅暴露会增加 个体的学校表现受损，冲动增加的可能性， 侵略性和违法行为。暴露于 环境神经毒性是一个复杂的互动网络 遗传，神经化学，生化，环境和社会因素 在关键时期影响儿童。迄今为止，研究 在人类发育的领域，神经毒理学主要集中在全球 感觉运动发展和认知的度量。但是，人类研究 阐明发育和行为障碍的生物学基础 由于环境有毒物质的暴露，缺乏。虽然大脑粗糙 结构看起来正常，潜在的问题必须在神经层面上存在。 该项目旨在将儿童环境铅暴露与 用磁性评估的大脑结构，神经化学和功能的变化 共振成像（MRI）和磁共振光谱（MRS）。皮质 皮层脑体积将通过高分辨率MRI确定。 神经元和神经胶质细胞标记（N-乙酰天冬氨酸，肌酸，胆碱和 肌醇）将使用质子MRS测量。这些结构和 化学措施也将与来自 辛辛那提铅研究（CLS）的年轻成人参与者。这些 参与者代表了大约240的独特而理想的研究队列 具有详细的暴露历史和行为结果的受试者 暴露的儿童受监测约20年。当这个队列进入 年轻成年，儿童铅暴露与反社会的关联 行为正在出现。 MRI和太太提供结构和代谢 与铅暴露相关的措施，行为措施的重要性是 有限的。一项试点研究（n = 40）检查语言，工作记忆和 注意与功能磁共振成像（fMRI）结合使用 还将进行更好地研究功能和功能的相关性 行为不足。