EXAMINING BREAST DISEASES W/ PROTON MR SPECTROSCOPY

使用质子磁共振波谱检查乳腺疾病

• 批准号: 6121059
• 负责人: KIM M CECIL
• 金额: $ 1.35万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121059
• 关键词: biomedical resource; clinical research; female; human subject; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; women's health

We have continued our research efforts at improving methods of detecting breast disease, especially cancer, using proton Magnetic Resonance Spectroscopy. Our hypothesis remains that breast carcinomas have higher levels of total choline concentration than those of benign breast lesions. Our studies were performed on a 1.5T clinical MR scanner using a custom-built four channel multicoil assembly which compresses the breast sagittally. We made use of contrast-enhanced MRI and single voxel proton MRS using STEAM at echo times of 31 and 270 msec. Over the past year, we have studied breast lesions in twenty-six women, and made pathologic correlations using needle biopsy or post-surgical specimens. This population had 17 women with malignant breast lesions and 9 women with benign processes. The MRS examination was performed by sampling nominal voxel sizes less than 4cc which were prescribed from the MR images. Spectra showed resonances from water and mobile fatty acids; in a majority of carcinomas, the N-trimethyl resonance of compounds containing choline at 3.2 ppm was present as well. Using the presence of Cho as a test for malignancy, the sensitivity and specificity of our entire patient population (N=55) were calculated at 79% and 95%, respectively. The positive and negative predictive values of this test were 96% and 75%. Spatially localized proton MRS can provide sufficient sensitivity and spectral resolution at 1.5 T to observe choline in human breast lesions. Testing for the presence of choline serves as a test for malignancy that is useful in characterizing breast lesion either on its own or in combination with MRI criteria.

我们继续努力研究改进 使用质子磁检测乳腺疾病，尤其是癌症 共振光谱学。 我们的假设是乳腺癌 总胆碱浓度高于良性肿瘤 乳腺病变 我们的研究在1.5T临床MR上进行 使用定制的四通道多线圈组件的扫描仪， 向矢状方向压迫乳房 我们使用了对比增强的 在回波时间为31时使用STEAM进行MRI和单体素质子MRS， 270毫秒。 在过去的一年里，我们研究了乳腺病变， 26名妇女，并使用针吸活检进行病理相关性 或者手术后的标本 这个群体有17名妇女， 乳腺恶性病变9例，良性病变9例。 的MRS 通过采样标称体素尺寸小于 4cc，根据MR图像规定。 光谱表明 来自水和移动的脂肪酸的共振;在大多数 癌，含胆碱化合物的N-三甲基共振 3.2ppm也存在。 利用赵的存在作为测试 对于恶性肿瘤，我们整个病人的敏感性和特异性 人群（N=55）的计算结果分别为79%和95%。 的 本试验的阳性和阴性预测值分别为96%和75%。 空间定位的质子MRS可以提供足够的灵敏度， 1.5T光谱分辨率观测人体乳腺胆碱 病变 测试胆碱的存在作为测试 恶性肿瘤是有用的，在表征乳腺病变或 其自身或与MRI标准结合。