PROTON MRS FOR DETECTING AXONAL PATHOLOGY IN SPLENIUM OF BRAIN INJURED PATS

用于检测脑损伤部位压部轴突病理的质子 MRS

• 批准号: 6121071
• 负责人: KIM M CECIL
• 金额: $ 2.44万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121071
• 关键词: biomedical resource; female; human subject; injury; magnetic resonance imaging; male; nuclear magnetic resonance spectroscopy

Proton MR spectroscopy provides a method for indicating axonal viability after traumatic brain injury. Proton MRS can readily detect levels of N-acetyl aspartate, a chemical synthesized exclusively in neurons and axons. Diffuse brain injury selectively injures white matter tracts because of the high inertial strain created as a result of rotational acceleration and deceleration. Proton MRS may be beneficial in evaluating traumatic brain injured patients, in vivo, for diffuse injury. This work focused upon determining the spectroscopic profile of the splenium in normal and traumatic brain injured patients. The corpus callosum, especially the splenium, is a vulnerable site for shearing forces producing DAI. The findings from our investigation was that NAA/Cr in the normal splenium is elevated compared to normal lobar white matter. The spectroscopic profile of the splenium is distinct from that of lobar white matter. Examination of thirty five cases of traumatic brain inju ry show a population with a significantly lower NAA/Cr in the splenium compared to normal control subjects. Twenty four of the thirty five cases showed lowered NAA/Cr compared to the mean NAA/Cr found in control subjects. Eleven cases with low NAA/Cr in the splenium had unremarkable or normal MRI examinations. All eleven cases suffered neurotrauma sequelae sufficient to require outpatient rehabilitation treatment. Declines in NAA/Cr of the splenium may be a marker for widespread diffuse injury. A proton MR spectroscopy examination may be of particular use for patients with mild brain injury having unexplained neurologic and cognitive deficits. The depletion of NAA upon neuronal and axonal shearing may be responsible for these deficits. Proton MR spectroscopy may prove a useful tool for determining this type of injury. Future efforts are focused upon utilizing multislice chemical shift imaging (CSI) techniques to examine regional NAA levels.

质子磁共振波谱提供了一种方法， 创伤性脑损伤后的生存能力 质子磁共振能轻易检测出 水平的N-乙酰天冬氨酸，一种化学合成专门在 神经元和轴突。 弥漫性脑损伤选择性伤害白色 由于产生的高惯性应变， 旋转的加速和减速。 质子MRS可能是 有益于在体内评估创伤性脑损伤患者， 弥漫性损伤 这项工作的重点是确定 正常和创伤性脑压区的光谱特征 受伤的病人。 胼胝体，尤其是压部，是一个 剪切力产生DAI的脆弱部位。 的结果 我们的研究表明，正常压部的NAA/Cr升高， 与正常肺叶白色物质相比。 的光谱分布 压部与叶白色物质的压部不同。 考试 在35例外伤性脑损伤病例中， 压部NAA/Cr显著低于正常 控制对象。 35例中有24例显示降低， NAA/Cr与对照受试者中发现的平均NAA/Cr相比。 十一 压部NAA/Cr值低者MRI无异常或正常 考试 11例患者均有神经创伤后遗症 足以要求门诊康复治疗。 下降 压部NAA/Cr可能是广泛弥漫性 损伤 质子磁共振波谱检查可能特别有用 对于患有轻度脑损伤的患者， 认知缺陷 NAA耗竭对神经元和轴突的影响 剪切可能是造成这些缺陷的原因。 质子磁共振 光谱学可以证明是用于确定这种类型的 损伤 未来的工作重点是利用多层化学品 偏移成像（CSI）技术，以检查区域NAA水平。