ASTHMA ETIOLOGY

提出的哮喘病因学项目的长期目标 哥伦比亚儿童环境健康中心（CCCEH） 阐明出生前和2岁以下接触的作用， 蟑螂、尘螨和啮齿类动物过敏原以及环境 有毒物质、可吸入颗粒物（PM/2.5）、柴油机尾气 颗粒物（DEP）和环境烟草烟雾（ETS），在过敏原 致敏和反复喘息。过敏原致敏和复发 已发现喘息是哮喘的早期预测因子。目前， 对产前和产后早期的影响知之甚少， 环境暴露对过敏原致敏和反复喘息的影响 2岁之前。我们的研究假设是：1）过敏原的风险 2岁以前的过敏和反复喘息增加， 环境暴露于蟑螂、尘螨和啮齿动物过敏原， PM/2.5、DEP和ETS; 2）过敏原暴露对 过敏原致敏性和反复喘息增加， PM/2.5、DEP和/或ETS;以及3）为了检验低血浆浓度可能导致高血压的假设， 抗氧化微量营养素（维生素A，C，E）的水平增加 婴儿对过敏原的易感性，使不良影响 抗氧化剂水平低的儿童的过敏原更大 微量营养素该项目的成果将促进知识 关于过敏原致敏和复发的早期风险因素 喘息和哮喘发作。

The long-term objective of the asthma etiology project of the proposed Columbia Center for Children's Environmental Health (CCCEH) is to elucidate the role of exposures, before birth and up to age 2, to cockroach, dust mite and rodent allergens and to the environmental toxicants, respirable particulate matter (PM/2.5), diesel exhaust particulate (DEP) and environmental tobacco smoke (ETS), in allergen sensitization and recurrent wheezing. Allergen sensitization and recurrent wheezing have been found to be early predictors of asthma. Currently, little is known about the effects of prenatal and early postnatal environmental exposures on allergen sensitization and recurrent wheezing before age 2. Our study's hypotheses are that 1) the risks for allergen sensitization and recurrent wheezing before age 2 are increased be environmental exposures to cockroach, dust mite, and rodent allergens and to PM/2.5, DEP and ETS; 2) the adverse effect of allergen exposure on allergen sensitization and recurrent wheezing is increased by exposure to PM/2.5, DEP and/or ETS; and 3) To test the hypothesis that low plasma levels of antioxidant micronutrients (vitamins A, C, E) increase the infant's susceptibility to allergens, so that the adverse effects of allergens are greater for children with low levels of antioxidant micronutrients. The results of the Project will advance the knowledge about early-life risk factors for allergen sensitization and recurrent wheezing and the onset of asthma.