Update of Duke Research SPECT System

需要资金来升级杜克SPECT研究仪器。总体目标是通过提供高性能、可靠和定量的SPECT研究仪器，在美国国立卫生研究院和其他联邦机构的支持下，促进仪器用户的研究进展。Duke SPECT研究仪器最初于1988年收购，主要得到NIH BRS共享仪器资助计划的支持。在过去的13年里，SPECT研究仪器一直被用作体内和体外研究的研究仪器。在此期间，杜克大学的研究人员设计和制造了几种独特的研究级准直器和专门的体模定位组件，可以与SPECT研究仪器一起使用。内部开发的研究用准直器包括：a)用于成像I-131标记的单抗治疗剂量的超高分辨率旋转平行孔准直器；b)用于获取传输数据以确定SPECT衰减图的对称和非对称半扇形束准直器；3)用于脑和乳腺成像的对称和非对称半锥形光束准直器；以及d)用于小动物成像的超高分辨率针孔准直器，以及用于I-131标记的单抗治疗剂量的超高分辨率成像。这些配件是用户组重要而独特的研究资源。它们的设计和建造需要大量的时间、精力和资金支持。目前的SPECT研究仪已经运行多年，满足了许多用户的需求，推动了他们的研究进展。目前，该仪器正在老化，越来越难以维护，而且有一些固有的特点限制了它作为一些用户应用的研究工具的整体有效性。例如，磁头的后退仅限于27厘米，从而显著减小了传输数据采集的视场。这项提议的一个重要目标是确保定制的研究准直器和专门组件与新升级的SPECT仪器保持兼容和功能。第二个目标是改进现有系统的固有性能特征。用新一代三探头SPECT仪器取代三探头SPECT仪器，可以很好地实现这两个目标。这一关键的SPECT实验室升级将确保用户继续拥有专用和高度定量的SPECT仪器，这将增强他们的研究进展，帮助他们实现长期研究目标，并允许他们研究定量成像的新技术和方法。

Funds are requested to upgrade the Duke SPECT Research Instrument. The overall goal is to enhance research progress of Instrument Users supported by the National Institutes of Health, and other federal agencies, by providing a high performance, reliable and quantitative SPECT Research Instrument The Duke SPECT Research Instrument was originally acquired in 1988, primarily with support from the NIH BRS Shared Instrumentation Grant Program. The SPECT Research Instrument has been used as a research instrument for the past 13 years for in vivo and vitro studies. Over this period Duke investigators have designed and built several unique research grade collimators and specialized phantom- positioning assemblies that can be used with the SPECT Research Instrument. The in-house developed research collimators include: a) an ultra-high resolution rotating parallel hole collimator for imaging therapeutic doses of I-131-labeled monoclonal antibodies (MAbs); b) symmetric and asymmetric half fan beam collimators for acquiring transmission data to determine SPECT attenuation maps; 3) symmetric and asymmetric half cone beam collimators for brain and breast imaging; and d) ultra-high resolution pinhole collimators for small animal imaging, and ultra-high resolution imaging of therapeutic doses of I-131- labeled MABS. These accessories are important and unique research resources for the User Group. Their design and construction required a significant investment in time, effort and financial support. The current SPECT Research Instrument has performed for many years, has served many of the Users' needs, and advanced their research progress. Presently the Instrument is aging and becoming increasingly difficult to maintain, and there are a few instrinsic characteristics that limit its overall effectiveness as a research instrument for some Users' applications. For example, retraction of the heads is limited to only 27 cm, thereby the field of view for transmission data acquisition is markedly reduced. An important objective of this proposal is to ensure that the custom research collimators and specialized assemblies remain compatible and functional with the newly upgraded SPECT Instrument. A second objective is to improve upon the present system's intrinsic performance characteristics. Both of these objectives can be successfully attained by replacing the triple head SPECT Instrument with a current generation triple head SPECT Instrument. This essential SPECT Laboratory upgrade will ensure that the Users continue to have a dedicated and highly quantitative SPECT instrument available that will enhance their research progress, help them to accomplish their long term research goals, and allow them to investigate new techniques and approaches to quantitative imaging.