CORE--ANIMAL BREEDING AND SURGICAL FACILITY

核心——动物饲养和手术设施

• 批准号: 6576560
• 负责人: THOMAS M COFFMAN
• 金额: $ 25.93万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6576560
• 关键词: animal breeding; animal colony; biomedical facility; kidney transplantation; laboratory mouse; microsurgery

Description: (Taken directly from the application) The Microsurgical Core (Core B) plays a central role in the strategies for achieving the specific objectives of this Program. All projects depend on the technical expertise of the Core B facility and this technical expertise is the foundation for the Program. As this Program was originally organized, it became obvious to all the investigators that in order for them to pursue studies in the area of renal transplantation, each would have to train one or two transplant technicians, equip surgical stations, and maintain populations of animals independently. By combining efforts in a Program Project that provided a core laboratory for maintaining animals and performing renal transplant surgery, a tremendous amount of money and effort could be saved. The numerous ongoing collaborations, the enthusiasm for the pursuit of studies in the area of transplantation and the legitimate need for the development of a Core facility provided the impetus for the original development of this Program Project. These circumstances have persisted and in fact the enthusiasm and demand for the Core services have steadily increased. The primary role of the Microsurgical Core facility continues to be providing mouse transplants to Project investigators. For the current proposal, the core will provide both kidney and heart transplants. This Core also provides capabilities for measuring renal transplant function as specified within the individual proposals. The techniques for transplantation and the experimental utilization of transplanted animals is described in detail in the individual Project proposals. The personnel and facilities have been described above in the justification. In brief, Dr. Coffman will have responsibility for managing the Core and Mr. Best and Mr. Griffiths will aid Dr. Coffman in the management of the facility. Quality control is monitored within the Core by the transplant technicians, the veterinary staff and Dr. Coffman. Prioritization is determined among the Project investigators and coordinated by the transplant technicians. The projected use of this facility over the first year is depicted in Distribution of Core Unit Costs Among Research Projects.

描述：(直接取自申请)显微外科核心(核心 B)在实现具体目标的战略中发挥核心作用 这一计划的。所有项目都依赖于核心B的技术专长 设施和这种技术专长是该计划的基础。AS 这个计划最初是有组织的，所有人都很清楚 研究人员说，为了让他们在肾脏领域进行研究 移植，每个人都要培训一到两名移植技术人员， 配备外科手术站，并独立维持动物种群。通过 在为以下项目提供核心实验室的计划项目中结合工作 维护动物和进行肾移植手术，这是一个巨大的 可以节省大量的金钱和精力。众多正在进行的合作， 对移植和移植领域研究的热情 开发核心设施的正当需要提供了动力 用于本计划项目的原始开发。在这些情况下 坚持并事实上对核心服务的热情和需求 稳步增长。 显微外科核心设施的主要作用继续是提供 将老鼠移植给项目调查人员。对于目前的提案，核心是 将提供肾脏和心脏移植。此核心还提供 中指定的测量肾移植功能的能力 个人提案。移植技术与实验 移植动物的利用在个人中有详细的描述。 项目建议书。人员和设施已在上文中描述。 辩解的理由。简而言之，科夫曼博士将负责管理 Core、Best先生和Griffiths先生将在管理方面协助Coffman博士 设施的一部分。通过移植来监控核心内的质量控制 技术人员、兽医人员和科夫曼医生。确定优先顺序 在项目调查人员之间，并由移植技术人员协调。 该设施在第一年的预计使用情况见 核心单位成本在研究项目中的分配。