CORE--ANIMAL BREEDING AND SURGICAL FACILITY

描述：（直接取自应用程序）显微外科核心（核心 B）在实现具体目标的战略中发挥核心作用 这个节目。所有项目都依赖于核心B的技术专长 该设施和这种技术专长是该计划的基础。作为 这个计划最初是有组织的，它变得明显，所有的 研究人员说，为了让他们在肾脏领域进行研究， 移植，每个人都必须培训一名或两名移植技术人员， 装备手术站，并独立维持动物种群。通过 在一个计划项目中结合努力，为以下项目提供核心实验室 维持动物和进行肾移植手术， 可以节省大量的金钱和精力。众多正在进行的合作， 对移植领域研究的热情， 发展核心基金的合理需要提供了动力 本项目的原始开发。这些情况 坚持，事实上，对核心服务的热情和需求已经 稳步上升。 显微外科核心设施的主要作用仍然是提供 小鼠移植给项目调查员对于目前的建议，核心 将提供肾脏和心脏移植该核心还提供 测量肾移植功能的能力， 个别提案。移植技术和实验 移植动物的利用在个体中详细描述。 项目提案。人员和设施已在上文中描述， 理由简而言之，科夫曼博士将负责管理 核心和贝斯特先生和格里菲斯先生将协助科夫曼博士管理 的设施。质量控制是由移植的核心监测 技术人员兽医人员和科夫曼医生确定优先顺序 在移植技术人员的协调下， 该设施在第一年的预计使用情况载于 核心单位成本在研究项目中的分布。

Description: (Taken directly from the application) The Microsurgical Core (Core B) plays a central role in the strategies for achieving the specific objectives of this Program. All projects depend on the technical expertise of the Core B facility and this technical expertise is the foundation for the Program. As this Program was originally organized, it became obvious to all the investigators that in order for them to pursue studies in the area of renal transplantation, each would have to train one or two transplant technicians, equip surgical stations, and maintain populations of animals independently. By combining efforts in a Program Project that provided a core laboratory for maintaining animals and performing renal transplant surgery, a tremendous amount of money and effort could be saved. The numerous ongoing collaborations, the enthusiasm for the pursuit of studies in the area of transplantation and the legitimate need for the development of a Core facility provided the impetus for the original development of this Program Project. These circumstances have persisted and in fact the enthusiasm and demand for the Core services have steadily increased. The primary role of the Microsurgical Core facility continues to be providing mouse transplants to Project investigators. For the current proposal, the core will provide both kidney and heart transplants. This Core also provides capabilities for measuring renal transplant function as specified within the individual proposals. The techniques for transplantation and the experimental utilization of transplanted animals is described in detail in the individual Project proposals. The personnel and facilities have been described above in the justification. In brief, Dr. Coffman will have responsibility for managing the Core and Mr. Best and Mr. Griffiths will aid Dr. Coffman in the management of the facility. Quality control is monitored within the Core by the transplant technicians, the veterinary staff and Dr. Coffman. Prioritization is determined among the Project investigators and coordinated by the transplant technicians. The projected use of this facility over the first year is depicted in Distribution of Core Unit Costs Among Research Projects.