CORE--NEUTRON ACTIVATION FACILITY

核心——中子活化装置

• 批准号: 6575632
• 负责人: F A DILMANIAN
• 金额: $ 14.86万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6575632
• 关键词: activation analysis; analytical method; biomedical facility; biotechnology; body composition; body physical characteristic; clinical research; computer system design /evaluation; human subject; mathematical model; morphometry; photon absorptiometry; technology /technique development

Core Unit B will provide Program Project Grant (PPG) investigators with three services: high precision whole-body in vivo neutron activation (IVNA) analysis measurements of H, C, N, O, Ca, P, Na, and C1, and whole-body counting for K; expert assistance with interpretation and analysis of IVNA results; and physics consultations for new instrument design and development. Instrumentation for high precision measurements of body composition by IVNA were developed and equipped with state-of-the-art hardware during PPG I. Subsequent improvements in the analytical strategies extended the range of subjects that were included in the studies during PPG II measurement precisions of the IVNA facilities were further improved using new and improved phantoms and by implementing a Monte Carlo code (MCNP) to carry out extensive simulations for different body configurations and stature. During this period extensive calibrations and cross-calibrations with investigators at Baylor for Ca and with investigators at Core Unit A for total body potassium (TBK), were carried out with publication of results. Replacement of older computers with newer systems enabled transfer from an early software environment to contemporary operating systems. These improvements along with basic operations upgrades allowed measurement routinely of up to six patients per week with stabilized systems. Core support during the proposed PPG III for clinical research projects will continue and important new initiatives will be instituted, including: new calibrations for measuring TBK and Ca in obese patients in Project 3; correlation of partial/regional body nitrogen to total body nitrogen with Core A; creation of independent MCNP input files that describe the human body as simulated by a BOMAB phantom for each of the three activation facilities; and design of a Gamma Nuclear Resonance Absorptiometry system for elemental imaging in vivo. The Core's activities are consistent with the Department of Energy's mandate to develop novel technologies, to transfer these systems to cooperating laboratories following their developing and testing phase, and to maintain state-of-the art systems for use as national and internal reference standards.

核心单元B将为计划项目资助（PPG）研究人员提供三项服务：H、C、N、O、Ca、P、Na和C1的高精度全身体内中子活化（IVNA）分析测量，以及K的全身计数; IVNA结果解释和分析的专家协助;以及新仪器设计和开发的物理咨询。在PPG I期间，开发了IVNA高精度测量身体成分的仪器，并配备了最先进的硬件。分析策略的后续改进扩大了PPG II期间研究中纳入的受试者范围，使用新的和改进的体模并通过实施Monte Carlo代码（MCNP）对不同的身体构型和身高进行广泛的模拟，进一步提高了IVNA设施的测量精度。在此期间，与Baylor的研究者进行了广泛的校准和交叉校准（钙），与核心单元A的研究者进行了广泛的校准和交叉校准（全身钾（TBK）），并发表了结果。用较新的系统取代较旧的计算机，使人们能够从早期的软件环境转移到当代的操作系统。这些改进沿着基本操作升级，允许使用稳定的系统每周对多达6名患者进行常规测量。在拟议的PPG III期间，将继续为临床研究项目提供核心支持，并将制定重要的新举措，包括：在项目3中测量肥胖患者TBK和Ca的新校准;部分/区域体氮与体氮总量与核心A的相关性;创建独立的MCNP输入文件，描述三个激活设施中每个设施的BOMAB体模模拟人体;以及用于体内元素成像的伽马核共振吸收测量系统的设计。该中心的活动符合能源部的任务规定，即开发新技术，在开发和测试阶段之后将这些系统转让给合作实验室，并保持最先进的系统，用作国家和内部参考标准。