Error detection by the olivocerebellar system and its role in motor adaptation
橄榄小脑系统的错误检测及其在运动适应中的作用
基本信息
- 批准号:2266950
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2019
- 资助国家:英国
- 起止时间:2019 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The main aim of this study is to understand how the Inferior Olivary nucleus (IO) contributes to cerebellar dependent motor learning. Motor learning is the process by which we acquire and store memories that encode movements 1. This is largely done by the cerebellum 2. By integrating information coming from the sensory systems and the spinal cord, it is able to assess the execution of each movement 2. When an actual motor output doesn't match the intended movement, changes are implemented 3. Cerebellar disorders are commonly associated with ataxias, that is a lack of control and coordination upon faster movements 4. The treatments available for cerebellar ataxias are limited with physical therapy being the most common form of care 5. With a deeper understanding on the neural computations underlying cerebellar learning, we can aid future efforts to understand and correct these conditions. The IO is postulated to be the site that detects the mismatch between the predicted and actual movement, by receiving an internal copy of a motor command as well as sensory input and consequently re-afferent information on the actual motor output 6. Upon mismatch, it generates a sensory error signal thought to be used for the online control of movement by the cerebellum, to enable motor adaptation to the changing environment 6,7. Despite its central role in motor learning, how the IO encodes this sensory error signal is unknown 7. Recording neural activity in the mammalian IO during a behavioural task, presents a series of complications and challenges. To overcome these challenges, this study will utilise the larval zebrafish as a model system 8. We can exploit its genetic amenability and optical transparency to use the latest imaging tools, one being Voltron 9. Voltron, a 'chemigenetic' voltage sensor will be expressed specifically in the IO neurons. A calcium reporter GCaMP 10, will be expressed brain-wide to report on neural activity across the entire brain. We will use the well-established Opto Motor Response (OMR), motor adaptation paradigm in a closed loop virtual reality setup 11,12. Since the stimulus will be in the experimenters' control, we can induce sensory prediction errors as the zebrafish is engaging in behaviour and have a comprehensive overview of IO and whole brain activity during this. The advantage to using Voltron enables us to not only see individual spike activity, but also subthreshold membrane fluctuations 9. We can relate both these aspects in IO activity to stimulus, behaviour and whole brain activity. Under the hypothesis that the IO encodes the sensory error signal used to guide cerebellar learning, we can use our techniques to test these key predictions: Firstly, we should record representations of the sensory environment and motor output in IO activity: The sign and amplitude of deviation of the actual movement from the predicted movement is seen in IO activity. Features of IO activity should predict the subsequent motor adaptation. Finally, by selective activation of the IO adhering to these features, we should 'trigger' the coinciding behaviour.
本研究的主要目的是了解下橄榄核(IO)如何参与小脑依赖性运动学习。运动学习是我们获取和储存编码运动的记忆的过程。这主要是由小脑2完成的。通过整合来自感觉系统和脊髓的信息,它能够评估每个运动2的执行。当实际电机输出与预期运动不匹配时,执行更改3.小脑疾病通常与共济失调有关,即在快速运动时缺乏控制和协调4。可用于小脑共济失调的治疗是有限的,物理治疗是最常见的护理形式5。随着对小脑学习背后的神经计算的深入了解,我们可以帮助未来的努力来理解和纠正这些情况。IO被假定为通过接收运动命令的内部副本以及感觉输入和因此关于实际运动输出6的再传入信息来检测预测和实际运动之间的失配的部位。在失配时,它会产生一个感觉错误信号,被认为是用于小脑对运动的在线控制,以使运动适应不断变化的环境6,7。尽管它在运动学习中的核心作用,IO如何编码这种感觉错误信号是未知的7。在行为任务期间记录哺乳动物IO中的神经活动,提出了一系列的并发症和挑战。为了克服这些挑战,本研究将利用斑马鱼幼虫作为模型系统8。我们可以利用它的遗传适应性和光学透明度来使用最新的成像工具,其中之一就是Voltron 9。Voltron是一种“化学发生”电压传感器,将在IO神经元中特异性表达。钙报告基因GCaMP 10将在全脑表达,以报告整个大脑的神经活动。我们将在闭环虚拟现实设置中使用成熟的视觉运动反应(OMR),运动适应范例11,12。由于刺激将在实验者的控制下,我们可以在斑马鱼参与行为时诱导感觉预测错误,并在此期间对IO和整个大脑活动进行全面概述。使用Voltron的优势使我们不仅可以看到单个尖峰活动,还可以看到阈下膜波动9。我们可以将IO活动中的这两个方面与刺激、行为和整个大脑活动联系起来。在IO编码用于指导小脑学习的感觉错误信号的假设下,我们可以使用我们的技术来测试这些关键预测:首先,我们应该记录IO活动中的感觉环境和运动输出的表征:在IO活动中可以看到实际运动与预测运动偏离的符号和幅度。IO活动的特点应该预测随后的运动适应。最后,通过选择性地激活与这些特征相一致的IO,我们应该“触发”巧合行为。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
-- - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
- 批准号:
2780268 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
相似国自然基金
Graphon mean field games with partial observation and application to failure detection in distributed systems
- 批准号:
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
基于深穿透拉曼光谱的安全光照剂量的深层病灶无创检测与深度预测
- 批准号:82372016
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
膀胱癌高表达基因UPK3A的筛选、鉴定和相关研究
- 批准号:81101922
- 批准年份:2011
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
图像分类方法研究及其在色情监测中的应用
- 批准号:61172103
- 批准年份:2011
- 资助金额:62.0 万元
- 项目类别:面上项目
基于隐半马尔科夫模型的无线传感器网络入侵检测系统研究
- 批准号:61101083
- 批准年份:2011
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
基于指令层次的网页木马渗透攻击机理分析与检测方法研究
- 批准号:61003217
- 批准年份:2010
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
超高速正则表达式匹配技术研究
- 批准号:61073184
- 批准年份:2010
- 资助金额:12.0 万元
- 项目类别:面上项目
低辐射空间环境下商用多核处理器层次化软件容错技术研究
- 批准号:90818016
- 批准年份:2008
- 资助金额:50.0 万元
- 项目类别:重大研究计划
制冷系统故障诊断关键问题的定量研究
- 批准号:50876059
- 批准年份:2008
- 资助金额:30.0 万元
- 项目类别:面上项目
相似海外基金
CAREER: Highly Rapid and Sensitive Nanomechanoelectrical Detection of Nucleic Acids
职业:高度快速、灵敏的核酸纳米机电检测
- 批准号:
2338857 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Continuing Grant
CRII: RI: Deep neural network pruning for fast and reliable visual detection in self-driving vehicles
CRII:RI:深度神经网络修剪,用于自动驾驶车辆中快速可靠的视觉检测
- 批准号:
2412285 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
ERI: Non-Contact Ultrasound Generation and Detection for Tissue Functional Imaging and Biomechanical Characterization
ERI:用于组织功能成像和生物力学表征的非接触式超声波生成和检测
- 批准号:
2347575 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Collaborative Research: Using Polarimetric Radar Observations, Cloud Modeling, and In Situ Aircraft Measurements for Large Hail Detection and Warning of Impending Hail
合作研究:利用偏振雷达观测、云建模和现场飞机测量来检测大冰雹并预警即将发生的冰雹
- 批准号:
2344259 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
NSF Convergence Accelerator Track L: Smartphone Time-Resolved Luminescence Imaging and Detection (STRIDE) for Point-of-Care Diagnostics
NSF 融合加速器轨道 L:用于即时诊断的智能手机时间分辨发光成像和检测 (STRIDE)
- 批准号:
2344476 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
CSR: Small: Multi-FPGA System for Real-time Fraud Detection with Large-scale Dynamic Graphs
CSR:小型:利用大规模动态图进行实时欺诈检测的多 FPGA 系统
- 批准号:
2317251 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Global Road Damage Detection with privacy-preserved collaboration
通过保护隐私的协作进行全球道路损坏检测
- 批准号:
24K17366 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Early-Career Scientists
Monolithic generation & detection of squeezed light in silicon nitride photonics (Mono-Squeeze)
单片一代
- 批准号:
EP/X016218/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
AI-powered portable MRI abnormality detection (APPMAD)
人工智能驱动的便携式 MRI 异常检测 (APPMAD)
- 批准号:
MR/Z503812/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
Examining the Function of a Novel Protein in the Cardiac Junctional Membrane Complex
检查心脏连接膜复合体中新型蛋白质的功能
- 批准号:
10749672 - 财政年份:2024
- 资助金额:
-- - 项目类别: