SPIRAL CT FOR COCHLEAR IMPLANTATION

人工耳蜗植入螺旋CT

• 批准号: 6634480
• 负责人: Ge Wang
• 金额: $ 22.52万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634480
• 关键词: X ray; anatomy; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; cochlear implants; computed axial tomography; computer program /software; electrodes; human subject; image processing; imaging /visualization /scanning; medical implant science; phantom model; stereophotography

DESCRIPTION: (as per applicant abstract) Multi-electrode, intracochlear implants are effective treatment of deafness, but the results vary between individuals. Pre- and post- operative spiral CT can provide 3D maps of cochlear morphology and electrode array position in the cochlea, subject to resolution limitations. Knowledge of 3D electrode locations relative to cochlear anatomy provides the foundation for modeling and investigation of electrical stimulation parameters to optimize speech recognition. There is a critical and immediate need to geometrically model the individual cochlea in vivo with precise anatomic localization of implanted electrodes. This geometric model is a prerequisite for development of electroanatomic models of the implanted cochlea, and may help explain part of intersubject speech recognition variability. Geometric relations between an electrode array and intracochlear features provide the basis for rational design of interventions, devices, and their programming. The long term objective is to define implanted cochlear morphology and improve speech recognition using this 3D geometric information. The specific aims are to (1) localize implant electrodes in 3D with post- operative X-ray sterophotogrammetry, and incorporate this information in corresponding spiral CT images; (2) deblur and unwrap the cochlea in volumetric spiral CT images pre- and post-operatively; (3) develop and validate geometric models of individual implanted cochleas, and demonstrate their clinical feasibility and utility in patient studies. Validation will be done with immage resolution phantoms, specimens of the human cochleas implanted with various types of cochlear implants, and cadaver heads in which these phantoms and specimens are embedded. The gold standard for validation will be established by independent measurements obtained using Reflex microscopy and micro CT of these phantoms and specimens. On completion, implanted cochlear morphology will be characterized in vivo by synthesizing individualized 3D geometric models based on X-ray stereophotogrammetry and spiral CT. X-ray imaging and image analysis methods for pre- and post-implantation diagnostic and research applications will be validated, and applied in patient studies. A Web- based resource of spiral CT for cochlear implantation will disseminate the image and modeling techniques and software.

描述：（根据申请人摘要）

项目成果

Artifacts associated with implementation of the Grangeat formula.

与实施 Grangeat 公式相关的工件。

• DOI: 10.1118/1.1522748
• 发表时间: 2002
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Lee,SeungWook;Cho,Gyuseong;Wang,Ge
• 通讯作者: Wang,Ge

Blind deblurring of spiral CT images-comparative studies on edge-to-noise ratios.

• DOI: 10.1118/1.1470500
• 发表时间: 2002-05
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: M. Jiang;Ge Wang;M. Skinner;J. Rubinstein;M. Vannier

Three-dimensional modeling and visualization of the cochlea on the Internet.

互联网上耳蜗的三维建模和可视化。

• DOI: 10.1109/4233.845207
• 发表时间: 2000
• 期刊: IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society.
• 作者: Yoo,SK;Wang,G;Rubinstein,JT;Skinner,MW;Vannier,MW
• 通讯作者: Vannier,MW

Three-dimensional localization of cochlear implant electrodes using epipolar stereophotogrammetry.

使用极立体摄影测量法对人工耳蜗植入电极进行三维定位。

• DOI: 10.1109/tbme.2004.826595
• 发表时间: 2004
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Yoo,SunK;Wang,Ge;Collison,Fred;Rubinstein,JayT;Vannier,MichaelW;Kim,HeeJ;Kim,NamH
• 通讯作者: Kim,NamH

X-ray micro-CT with a displaced detector array: application to helical cone-beam reconstruction.

具有移位探测器阵列的 X 射线微 CT：在螺旋锥束重建中的应用。

• DOI: 10.1118/1.1609058
• 发表时间: 2003
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Liu,Vinson;Lariviere,NicholasR;Wang,Ge
• 通讯作者: Wang,Ge