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CORE--SOLID TUMOR PHARMACOLOGY

CORE--SOLID TUMOR PHARMACOLOGY
核心--实体瘤药理学
批准号：
6654035
负责人：
CLINTON F STEWART
金额：
$28.58万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-09-06 至 2003-06-30
来源：
https://reporter.nih.gov/project-details/6654035
关键词：
DNA topoisomerases antineoplastics bioassay biomedical facility data collection methodology /evaluation drug screening /evaluation enzyme linked immunosorbent assay genotype high performance liquid chromatography histology liquid chromatography mass spectrometry microdialysis neoplasm /cancer pharmacology pediatric neoplasm /cancer pharmacokinetics topotecan western blottings

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DESCRIPTION (provided by applicant): The functions of the Solid Tumor Pharmacology Core are to: A. Perform assays to quantitate drug and drug metabolite concentrations in biological specimens collected from animals and patients as part of preclinical and clinical pharmacokinetic studies within this program. B. Analyze pharmacokinetic data obtained from preclinical and clinical pharmacokinetic studies, and fit appropriate pharmacokinetic and pharmacodynamic models to the data, as requested by investigators in this program. C. Perform genotyping studies on patient samples from clinical trials on Project 6 of this Program. D. Maintain computer databases of data from analyses performed in the Solid Tumor Pharmacology Core, and generate data retrievals and reports as required. E. Perform additional special laboratory procedures as required to support the projects included in this program.
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