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SOLID TUMOR PHARMACOLOGY CORE

实体瘤药理学核心

基本信息

批准号：
8309819
负责人：
CLINTON F STEWART
金额：
$ 31.08万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8309819
关键词：
Angiogenesis Inhibitors Animal Experiments Animals Antibodies Antineoplastic Agents Biological Biological Assay Biological Models CCI-779 Cancer Center Cancer Center Support Grant Child Childhood Solid Neoplasm Clinic Clinical Clinical Research Clinical Trials Computers Conduct Clinical Trials Consultations Core Facility Cytostatics Cytotoxic agent Data Data Analyses Data Reporting Data Storage and Retrieval Databases Developmental Therapeutics Program Doctor of Medicine Doctor of Philosophy Drug Kinetics Exposure to Funding Future Genotype Grant Individual Investigation Laboratory Procedures Malignant Childhood Neoplasm Measures Methods Modeling Outcome Patients Pharmaceutical Preparations Pharmacodynamics Pharmacogenetics Pharmacology Plasma Pre-Clinical Model Procedures Process Program Research Project Grants Quality Control Reagent Recommendation Research Research Personnel Resource Sharing Resources Role Sampling Scientist Services Signal Transduction Solid Neoplasm Specific qualifier value Specimen Testing Therapeutic Therapeutic Studies Tissues Toxic effect Translations Validation Work Xenograft procedure base chemosensitizing agent design kinase inhibitor member novel novel therapeutics pharmacodynamic model pharmacokinetic model pre-clinical preclinical evaluation programs research clinical testing response small molecule

项目摘要

The functions of the Solid Tumor Pharmacology Core are to: A. Perform assays to quantitate drug and drug metabolite concentrations in biological specimens collected from animals and patients as part of preclinical and clinical pharmacokinetic studies within this Program. B. Analyze pharmacokinetic data obtained from preclinical and clinical pharmacokinetic studies, and fit appropriate pharmacokinetic and pharmacodynamic models to the data, as requested by investigators in this Program. C. Perform genotyping studies on patient samples from clinical trials conducted within this Program. D. Maintain computer databases of data from analyses performed in the Solid Tumor Pharmacology Core, and generate data retrievals and reports as required. E. Perform additional special laboratory procedures as required to support the projects included in this Program.

实体瘤药理学核心的功能是： A. 进行测定以定量收集的生物样本中的药物和药物代谢物浓度作为本计划中临床前和临床药代动力学研究的一部分，来自动物和患者。 B. 分析从临床前和临床药代动力学研究获得的药代动力学数据，并拟合根据本研究中研究者的要求，对数据进行适当的药代动力学和药效学模型程序。 C. 对本计划内进行的临床试验的患者样本进行基因分型研究。 D. 维护实体肿瘤药理学核心中进行的分析数据的计算机数据库，并根据需要生成数据检索和报告。 E. 根据需要执行额外的特殊实验室程序以支持本报告中包含的项目程序。