MECHANISMS OF TIME DISCRIMINATION

时间歧视机制

• 批准号: 6659912
• 负责人: JONATHON D CRYSTAL
• 金额: $ 18.1万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-12 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6659912
• 关键词: behavior test; behavioral /social science research tag; biological clocks; bioperiodicity; circadian rhythms; ethology; laboratory rat; learning; methamphetamine; psychobiology; time perception

DESCRIPTION (provided by applicant): Efforts to understand the discrimination of time have proceeded along two relatively independent paths, one focusing on timing short intervals and one focusing on timing intervals of approximately a day. These efforts have studied different experimental manipulations and dependent variables, constructed different theoretical frameworks, and communicated findings to different research communities. These factors have led to the conclusion that the timing of short intervals and circadian rhythms are based on unrelated mechanisms. However, recent findings about the discrimination of short and circadian intervals suggest similarities in these two domains and raise the prospect of advancing the knowledge base of timing by examining the continuum of timing from short interval to circadian ranges. The long-range goal is to develop a theory of timing that encompasses the discrimination of temporal intervals across several orders of magnitude from milliseconds to days. The objective of this application is to exploit strong features of short interval and circadian approaches to identify mechanisms of short-interval time discrimination. The central hypothesis is that multiple oscillators, with periods that range from milliseconds to days, underlie time discrimination. The mechanism underlying local maxima in sensitivity to time will be examined in the short-interval domain. The working hypothesis is that each established local maximum in timing is based on an oscillator mechanism. Properties of oscillator and accumulator mechanisms will be tested by examining self-sustaining free-running rhythms, entrainment boundaries, and phase-response curves in short-interval timing. The relation between multiple local maxima in sensitivity to time will be determined. The working hypothesis is that a circadian oscillator synchronizes short-interval oscillators in a multi-oscillator system. Coupling between oscillators will be tested by correlating free-running periods in short-interval timing and manipulating the circadian system and testing properties of the short-interval system. The proposed research is expected to demonstrate (1) that local maxima in sensitivity to time are based on an oscillator mechanism, (2) the coupling relationship among multiple oscillators, and (3) that new mechanisms of time discrimination can be identified by integrating short-interval and circadian approaches. This integration is expected to have a major impact on short-interval and circadian fields because the current assumption of independence between these domains has not been tested and new advances will emerge from identifying common mechanisms.

描述（由申请人提供）：理解时间辨别的努力沿着沿着两条相对独立的路径进行，一条关注于计时短间隔，一条关注于大约一天的计时间隔。 这些努力研究了不同的实验操作和因变量，构建了不同的理论框架，并将研究结果传达给不同的研究团体。 这些因素导致了这样的结论，即短时间间隔和昼夜节律的时间是基于不相关的机制。 然而，最近的研究结果表明，在这两个领域的相似之处短和昼夜节律的间隔的歧视，并提出了前景的知识基础的时间，通过检查连续的时间从短时间间隔到昼夜节律的范围。 长期目标是发展一种计时理论，包括从毫秒到天的几个数量级的时间间隔的歧视。 本申请的目的是利用短间隔和昼夜方法的强大功能来识别短间隔时间歧视的机制。 核心假设是多个振荡器，周期从毫秒到几天不等，是时间辨别的基础。 局部最大灵敏度对时间的潜在机制将在短间隔域中进行检查。 工作假设是，每个建立的局部最大定时是基于振荡器机制。 振荡器和累加器机制的属性将通过检查自我维持的自由运行的节奏，夹带边界，和相位响应曲线在短时间间隔计时进行测试。 将确定多个局部最大值对时间的敏感性之间的关系。 工作假设是，在多振荡器系统中，昼夜节律振荡器取代短间隔振荡器。 振荡器之间的耦合将被测试相关的自由运行周期在短时间间隔计时和操纵昼夜节律系统和测试属性的短时间间隔系统。 该研究预计将证明：（1）对时间敏感性的局部最大值是基于振荡器机制，（2）多个振荡器之间的耦合关系，以及（3）通过整合短间隔和昼夜节律方法可以识别新的时间辨别机制。 这种整合预计将产生重大影响的短时间间隔和昼夜节律字段，因为目前的假设，这些领域之间的独立性还没有得到测试，新的进展将出现从确定共同的机制。