Clinical Research and Mentoring in Infectious Disease

描述（由申请人提供）：本提案的目的是为医学博士肯特塞普科维茨在以患者为导向的研究和指导年轻传染病教师和研究员领域的职业发展活动提供工资支持。Sepkowitz博士是临床传染病科的负责人，并以此身份监督MSKCC的所有传染病临床研究项目。他也是传染病奖学金培训计划的项目主任，并监督所有传染病研究员的职业发展。Sepkowitz博士的学术重点是卫生保健工作者的感染控制和职业感染。该奖项将使塞普科维茨博士能够进一步发展他的预防中心计划，该计划于1998年由CDC赠款支持建立，并资助到2006年。四个活动在此授权，包括两个预防中心项目：艰难梭菌的分子流行病学检查和手术部位监测的新方法。除了预防Epicenter倡议外，该奖项还将允许CDC资助的卫生保健工作者安全（NaSH）计划的进一步发展，以检查更安全的针头对针刺伤害率和类型的影响。最后一项活动是加强临床试验，重点是预防和治疗癌症患者机会性真菌和病毒感染的新疗法。塞普科维茨有一个与初级教师，研究员和居民富有成效的合作的既定记录。身份证服务最近增加了五名初级教员，每人负责一个特定的机构计划。新的初级教师和ID研究员将深入参与本申请中描述的四个研究项目。该奖项提供的资源将使塞普科维茨博士减少临床和行政责任，并提供具体的，预定的时间来指导初级教师和研究员，以确保他们的职业生涯的成功发展。此外，这将使他能够将更多的时间投入到具体的项目，感染控制计划和MSKCC预防中心的开发上。强大的学术传统和MSKCC的环境相结合，建立了联邦政府资助的感染控制计划（预防Epicenter），以及申请人与年轻医生有效合作的既定记录将产生一代具有临床研究专业知识的学术传染病医生。

DESCRIPTION (provided by applicant): The purpose of this proposal is to provide salary support for Kent Sepkowitz, MD, in his career development activities in the areas of patient oriented research and mentoring young infectious disease faculty and fellows. Dr. Sepkowitz is Head, Clinical Infectious Disease Section, and in this capacity supervises all infectious disease clinical research projects at MSKCC. He also is the Program Director for the infectious disease fellowship training program and oversees the career development of all infectious disease fellows. Dr. Sepkowitz's academic focus is infection control and occupational infections in health care workers. The award will allow Dr. Sepkowitz to further develop his Prevention Epicenter program, established by CDC grant support in 1998 and funded through 2006. Four activities are described in this grant, including two Prevention Epicenter projects: examination of the molecular epidemiology of Clostridium difficile and novel approaches to surgical site surveillance. In addition to Prevention Epicenter initiatives, the award will allow additional development of a CDC-funded program in health care worker safety (NaSH) examining the effect of safer needles on the rates and types of needlestick injuries. The final activity is enhanced clinical trials, which focus on new therapies for the prevention and treatment of opportunistic fungal and viral infections in cancer patients. Dr. Sepkowitz has an established record of collaborating productively with junior faculty, fellows, and residents. The ID Service has recently added five junior faculty members, each responsible for a specific institutional program. Both the new junior faculty and the ID fellows will be deeply involved in the four research projects described in this application. Resources provided by this award will allow Dr. Sepkowitz to cut back on clinical and administrative responsibilities and provide specific, scheduled time to mentor junior faculty and fellows, to assure successful development of their careers. In addition, it will allow him to devote more time to the specific projects, to the infection control program, and development of the MSKCC Prevention Epicenter. The combination of the strong academic tradition and milieu of MSKCC, the established, federally-funded program in infection control (Prevention Epicenter), and the applicant's established record of working productively with young physicians will produce a generation of academic infectious disease physicians with expertise in clinical investigation.