PHARMACOLOGY OF ANTIRETROVIRAL DRUGS IN GENITAL TRACT

描述：（改编自应用程序）此应用程序的目标是 职业中期奖以病人为导向的研究是为了支持一个实质性的 将调查员的专业学术职业发展方向改为 注重假设驱动 研究者发起的临床 药理学 研究，同时大幅增加对研究员的指导 和从事以病人为导向的研究的初级教员。 具体来说，这 奖项有 以下目标：1. 建立更加 聚焦线 药理学研究 其中，建筑 于 候选人现有 药理学研究工作，将开始一个新的长期项目， 定义抗逆转录病毒药物的药代动力学， 这些药物对艾滋病毒负荷的药效学作用在几个 隔室 的 生殖器 肠道 目的 优化 抗逆转录病毒疗法 为 预防 传输和 从药物庇护所中根除艾滋病毒; 2.提供更广泛的数字 临床研究人员的教育和后勤支持， 临床药理学研究单位，已组织，以促进 有效设计、执行、分析和报告假设驱动的 药代 和药效学 研究 研究横跨 许多 治疗学科;和3. 提供强化的一对一辅导， 初级教师和博士后研究员建立的基础， 在以患者为导向的研究中，富有成效的学术研究事业。该奖项 将允许候选人放弃目前的大量行政和 合同研究职责占用了他的研究目标的时间， 从 辅导 初级 医学科学家 兴趣 在 临床 调查 该奖项提供的受保护时间将允许他 扩大他目前的研究工作，更集中地关注 艾滋病毒相关药物的新用途和新的临床研究项目， 可能对艾滋病毒流行产生重大影响。同时， 奖励将允许候选人增加时间可以花在培养 少年发展 调查人员通过更多 强化导师制 在这项研究的背景下。

DESCRIPTION: (Adapted from the application) The goal of this application for a Mid-career Award for Patient-Oriented Research is to support a substantial redirection of the investigators professional academic career development to focus on hypothesis-driven investigator-initiated clinical pharmacology research in conjunction with a substantive increase in mentoring of fellows and junior faculty engaged in patient-oriented research. Specifically, this award has the following aims: 1. Establish a more focused line of pharmacologic research which, building upon the candidate s existing pharmacologic research efforts, will begin with a new long-term project to define the pharmacokinetics of antiretroviral drugs in relation to the pharmacodynamic effects of these drugs on HIV burden in each of several compartments of the genital tract with the purpose of optimizing antiretroviral regimens for both the prevention of transmission and eradication of HIV from pharmacologic sanctuaries; 2. Provide a broader number of clinical researchers with the educational and logistical support of the Clinical Pharmacology Research Unit which has been organized to facilitate the efficient design, execution, analysis, and reporting of hypothesis-driven pharmacokinetic and pharmacodynamic research studies across numerous therapeutic disciplines; and 3. Provide enhanced one-on-one mentorship to junior faculty and post-doctoral fellows to establish the foundations of productive academic research careers in patient-oriented research.This award will allow the candidate to relinquish substantial current administrative and contract-research duties that have taken time away from his research goals and from mentoring junior physician-scientists interested in clinical investigation. The protected time that the award provides will allow him to expand his current research efforts with a more consolidated focus on the novel use of HIV-related drugs and on new clinical research projects with potential for substantial impact on the HIV epidemic. Simultaneously, the award will allow the candidate to increase the time can spend fostering the development of junior investigators through more intensive mentorship activities in the context of this research.