Investigating Obesity-Cellular Physiology Interactions Underlying Multiple Chronic Age-Related Diseases

研究多种慢性年龄相关疾病背后的肥胖与细胞生理学相互作用

• 批准号: 2269875
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2269875
• 关键词: Investigating; Obesity; Cellular; Physiology; Interactions

Aging is associated with increased abdominal obesity, which is a stronger and joint risk factor for multipleage-related disorders (ARDs). Therefore, the elderly are exposed to increased risk for these disorders, andan expansion of obesity-related comorbidities is predicted at great cost to health and society. Obesityis a complex disease composing of multiple pathophysiological features, such as higher levels of fats andsugars in the blood. We hope to identify which features of obesity are most important for predicting thelikelihood of ARDs, and identify how they interact with our body on a cellular level. Online databases willbe utilised to find important obesity features, and establish which genes are affected by these features tojointly contribute to the development of ARDs. Changes in the ability for cells to detect and respond tolow oxygen plays an important role in the development and/or severity of multiple ARDs, such as heartattack mortality and cancer growth. We will directly investigate the role of fats on the ability for cells torespond to low oxygen, and whether this obesity-related mechanism contributes to ARDs. Ultimately, wehope to provide high-priority physiological markers for measuring and managing obesity, and allow for moreinformed dietary advice, which will have the largest impact on health and society.

衰老与腹部肥胖增加有关，腹部肥胖是多发性疾病（ARDs）的一个更强的联合危险因素。因此，老年人暴露于这些疾病的风险增加，预计肥胖相关的合并症的扩大将对健康和社会造成巨大损失。肥胖是一种复杂的疾病，包括多种病理生理特征，如血液中的高水平脂肪和糖。我们希望能够确定肥胖的哪些特征对于预测ARDs的可能性最重要，并确定它们如何在细胞水平上与我们的身体相互作用。在线数据库将被用来发现重要的肥胖特征，并确定哪些基因受这些特征的影响，从而共同促进ARDs的发展。细胞检测和响应低氧的能力的变化在多种ARDs的发展和/或严重程度中起着重要作用，例如心脏病发作死亡率和癌症生长。我们将直接研究脂肪对细胞对低氧反应能力的作用，以及这种肥胖相关机制是否会导致ARDs。最终，我们希望为测量和管理肥胖提供高优先级的生理标志物，并允许更多的饮食建议，这将对健康和社会产生最大的影响。